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Sandimmun 50mg Injection
Prescription Required
Salt Composition : Cyclosporine
Manufacturer : NOVARTIS INDIA LTD
Origin of Medicine : Switzerland
1 Ampoule(s) Of 1ml
Introduction to Sandimmun 50mg Injection
Sandummun 50mg Injection contains the active ingredient Cyclosporine. It is a medication that belongs to a class of drugs known as immunosuppressants. It is primarily used to prevent organ rejection in patients who have undergone organ transplantation, such as kidney, liver, or heart transplants. It is used with other medicines to prevent the rejection of the new organ by the body's immune system. After solid organ transplantation, the body generates an aggressive immune response because it recognizes the transplanted organ's antigens as foreign antigens. Thus, treatment with immunosuppressive agents is necessary after an organ transplant to prevent organ rejection.Â
Immunosuppressants increase the risk of skin cancer. Limit your exposure to the sun, wear protective clothing, and use sunscreen with high SPF. Inform your physician if you have recently taken vaccination with live vaccines. Sandummun 50mg Injection should not be used in individuals with known hypersensitivity or allergy to Sandummun 50mg Injection or its components. This medication can raise blood pressure levels. It should be used cautiously or avoided in individuals with uncontrolled high blood pressure or a history of hypertension. Discussing potential reproductive effects with a healthcare professional, especially for individuals planning to conceive, is important. Diabetes monitoring is important, especially for individuals at risk.
Uses of Sandimmun 50mg Injection
- Prevention of organ rejection (Kidney, liver, and heart)
- Treatment of Rheumatoid arthritis and Psoriasis
Therapeutic Effects of Sandimmun 50mg Injection
By suppressing the immune system, Sandummun 50mg Injection helps prevent organ rejection in transplant recipients. After organ transplantation, the immune system recognizes the transplanted organ as foreign and launches an immune response to attack and reject it. Sandummun 50mg Injection inhibits the activation of T-cells, a type of white blood cell involved in immune responses. This suppression of T-cell activity helps to prevent the immune system from attacking and damaging the transplanted organ, thereby increasing the chances of successful organ transplantation.
Interaction of Sandimmun 50mg Injection with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications interact with Sandummun 50mg Injection and reduce its effectiveness by causing undesirable side effects.
More Information about Sandimmun 50mg Injection
- Store this medication below 30°C
- Protect the medicine from light and excessive moisture.
- Keep the medicine out of reach of children and pets
- Take only a partial dose to make up for a forgotten dose.
How to consume Sandimmun 50mg Injection
It is an orally available prescription drug. Your doctor will decide the dose and duration of Sandummun 50mg Injection based on the disease condition and other factors such as body weight and age. Always take this medicine as prescribed by your doctor. Take the tablet at the same time, either with or without food. Do try to break, chew, or crush the tablet. Swallow the whole tablet with a glass of water.Â
Safety Advices for Sandimmun 50mg Injection
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Pregnancy
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If you are taking Sandummun 50mg Injection and are planning to become pregnant or are already pregnant, it is important to discuss this with your healthcare professional.
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Breast Feeding
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Sandummun 50mg Injection can pass into breast milk. Mothers receiving treatment with it should not breastfeed.
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Lungs
  It is unknown whether Sandummun 50mg Injection can be administered in patients with lung diseases. Inform your physician if you have any lung diseases before initiating the therapy.Â
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Liver
  Sandummun 50mg Injection should be used cautiously in individuals with liver impairment or pre-existing liver disease. This is because this medication is primarily metabolized in the liver, and impaired liver function can affect the metabolism and clearance of the medication from the body.
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Alcohol
 ÂIt is unsafe to drink alcohol while taking Sandummun 50mg Injection. It may reduce the drug's effectiveness and can cause toxic side effects.
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Driving
  Sandummun 50mg Injection can cause dizziness. It is recommended to avoid driving and operating heavy machinery during the treatment.Â
Side Effects of Sandimmun 50mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious
- Kidney damage
- Liver damage
- Infection, fever or sore throat
- Lack of coordination
- Memory problems
- Difficulty in speaking
- Visual problems
- Seizures
- Confusion
- Personality changes
- Sleeplessness
- Agitation
CommonÂ
- Hypertension
- Electrolyte imbalance
- Increased level of potassium in the blood
- Tremor
- Abnormal hair growth
- Enlargement of gum tissues
- Low levels of magnesium
- Risk of infections
- Headache
- Gastrointestinal disturbances
Word of Advice
When using Sandummun 50mg Injection, it is important to take several precautions. These include monitoring infections, kidney and liver function, blood pressure, and neurological symptoms closely. Abruptly stopping this medication can increase the risk of rejection in organ transplant patients or worsening autoimmune conditions. Pregnant and breastfeeding women should consult a doctor before taking it. Regular skin examinations and vigilance for signs of malignancies are advised. Allergic reactions should be promptly addressed. Awareness of potential drug interactions and gastrointestinal side effects is crucial. Regular blood tests to monitor blood cell counts and electrolyte levels are essential. Diabetes monitoring is important, especially for individuals at risk. Pediatric and geriatric patients require special consideration. Psychological effects should be monitored, and close consultation with healthcare professionals is necessary to ensure safe and effective use of it.
FAQs
Q 1. Can I consume grapefruit or grapefruit juice while taking Sandummun 50mg Injection?
No, avoiding consuming grapefruit or grapefruit juice while taking Sandummun 50mg Injection is generally advised. Grapefruit can interfere with the metabolism of this medication, leading to increased levels of the medication in the body, which can be potentially harmful.
Q 2. Can I receive vaccinations while on Sandummun 50mg Injection?
Vaccinations are generally safe and recommended for individuals taking Sandummun 50mg Injection. However, live vaccines may be contraindicated due to the immunosuppressive effects. It is important to consult your healthcare professional regarding the timing and suitability of vaccinations while on this medication.
Q 3. Can Sandummun 50mg Injection cause kidney or liver damage?
Sandummun 50mg Injection has the potential to cause kidney and liver damage. Regular monitoring of kidney and liver function through blood tests is crucial to detect any abnormalities early on. If you experience symptoms such as decreased urine output, yellowing of the skin or eyes, or abdominal pain, inform your healthcare professional promptly.
Q 4. How can I manage the increased blood pressure associated with Sandummun 50mg Injection?
Regular monitoring of blood pressure is important while taking Sandummun 50mg Injection. If your blood pressure increases significantly, your healthcare professional may recommend lifestyle modifications such as dietary changes, exercise, and, in some cases, medication to control hypertension.
Q 5. Can I abruptly stop taking Sandummun 50mg Injection?
Abruptly stopping Sandummun 50mg Injection can increase the risk of organ rejection in transplant patients or worsening of autoimmune conditions. If necessary, it is important to follow your healthcare professional's guidance regarding the gradual tapering or discontinuation of this medication.
Q 6. What Are the Effects of Sandummun 50mg Injection on Blood?
Sandummun 50mg Injection can affect blood cell counts, increasing the risk of infection, bleeding, and anemia. Regular blood tests should be conducted to monitor blood cell counts and detect abnormalities.
Q 7. Can Sandummun 50mg Injection Cause Diabetes?
Sandummun 50mg Injection may lead to the development of new-onset diabetes mellitus or exacerbate existing diabetes. Regular monitoring of blood glucose levels is recommended, especially in individuals with risk factors for diabetes.
Q 8. Can Sandummun 50mg Injection increase the risk of developing certain types of cancer?
Sandummun 50mg Injection has been associated with an increased risk of developing certain types of cancer, particularly skin cancers and lymphomas. It is important to undergo regular skin examinations and promptly report any unusual skin growths or changes to your healthcare professional. They can monitor for signs of cancer and provide appropriate management.
Fact Box of Sandimmun 50mg Injection
Molecule name: Cyclosporine | Therapeutic class:Â Immunosuppressants |
| Pharmacological class: Immunosuppressant agents. | Indications:Â 1. Prevention of organ rejection (Kidney, liver, and heart) 2. Treatment of Rheumatoid Arthritis and Psoriasis |
References
- Novartis, US Food and Drug Administration, [Revised on Sep 2009] [Accessed on 25th May, 2021], https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/050715s027,050716s028lbl.pdf
- Novartis Pharmaceuticals UK Limited, Electronic Medicines Compendium (EMC), [Revised on March 2023] [Accessed on 25th May 2023], https://www.medicines.org.uk/emc/files/pil.1034.pdf
- KD Tripathi, Immunosuppressant Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019,.937-945.
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