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Simponi 50mg Injection
Prescription Required
Salt Composition : Golimumab
Manufacturer : JOHNSON & JOHNSON PVT LTD
Origin of Medicine : United States of America
1 Prefilled Syringe(s) Of 0.5ml
Program Overview: JOHNSON & JOHNSON PVT LTD, Patient Assistance Program (PAP) is dedicated to helping patients in need of Simponi 50mg Injection. The program aims to provide eligible patients with access to the medication at a more affordable cost.
Program Benefits: Patient assistance programs (PAPs) are sponsored by pharmaceutical companies, and are an important step towards lowering overall therapy costs for patients. The purpose of these initiatives is to provide financial assistance to patients so they can obtain drugs at low or no cost. MrMed will guide you through the procedure and ensure you receive your PAP medication correctly.Â
Contact us for the latest updates on this exclusive offer.
Eligibility Criteria: To qualify for the Simponi Patient Assistance Program (PAP), you must meet specific criteria, including having a valid prescription for Golimumab 250mg from a medical rheumatologist and being an Indian patient with a valid identity card. Eligibility is determined based on the diagnosed condition and program-specific requirements.
Contact Information: If you have any questions or need assistance with the application process, our dedicated patient support team is here to help. You can reach us by phone at 89391 69999 or email us at [email protected].
Please note that MrMed is not involved in the PAP program. They offer free consultations to patients to provide information about the program. Patients eligible for the PAP program by Johnson & Johnson pvt ltd can avail of it without having to purchase the medication from MrMed.
Introduction to Simponi 50mg Injection
Simponi 50mg injection contains an active component as Golimumab. It is a monoclonal antibody drug used to treat autoimmune diseases, particularly certain inflammatory conditions. It works by targeting and inhibiting a certain protein, which plays a role in causing inflammation in the body. It is used to treat moderate to severe rheumatoid arthritis in adults, often in combination with other disease-modifying antirheumatic drugs (DMARDs). It is also approved for treating psoriatic arthritis, an autoimmune condition affecting joints and skin. It can treat ankylosing spondylitis, a type of arthritis primarily affecting the spine and sacroiliac joints. One of the advantages of this medication is that it offers relatively long dosing intervals compared to other biological medications.Â
Simponi 50mg injection should not be used in patients with known hypersensitivity or severe allergic reactions to the drug. Allergic reactions can be life-threatening and may include symptoms such as rash, itching, swelling, severe dizziness, and difficulty breathing. This medication can suppress the immune system, making patients more susceptible to infections. Individuals with active infections should start treatment once the infection is resolved. Individuals with a history of hepatitis B infection should require close monitoring before starting treatment, as the virus can reactivate during treatment. Patients with a history of heart failure or other significant cardiovascular conditions require close monitoring. Simponi 50mg injection's safety and efficacy in pediatric patients may differ from its use in adults. Older individuals may be at a higher risk of osteoporosis and fractures. The impact of this medication on bone health should be monitored, especially if the patient is already at risk. Patients with kidney impairment may require dose adjustments, as the clearance of these medications, is affected by impaired kidney function.
Uses of Simponi 50mg Injection
Simponi 50mg injection is used in the treatment of the following:
- Rheumatoid arthritis
- Psoriatic arthritis
- Ankylosing spondylitis
- Axial spondyloarthritis
- Ulcerative colitis
- Juvenile idiopathic arthritis
Therapeutic Effects of Simponi 50mg Injection
Golimumab in Simponi 50mg injection exerts its therapeutic effect through its role as a tumor necrosis factor-alpha (TNF-alpha) inhibitor. TNF-alpha is a cytokine involved in promoting inflammation and immune responses. This medication binds to soluble and transmembrane forms of TNF-alpha, preventing their interaction with cell surface receptors and dampening the downstream inflammatory signalling pathways. By inhibiting TNF-alpha, this medication helps reduce inflammation, alleviate symptoms, and slow the progression of autoimmune diseases such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis.
Interaction of Simponi 50mg Injection with other drugs
Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Simponi 50mg injection, reducing effectiveness by causing undesirable side effects.Â
More Information about Simponi 50mg Injection
- Stored in a refrigerator at a temperature between 2°C to 8°C.
- Keep away from moisture, heat, and light.
- It should not be frozen.
- Keep away from children and pets.
How to consume Simponi 50mg Injection
Simponi 50mg injection is typically administered as a subcutaneous injection, which involves injecting the medication under the skin. The exact method of administration may vary depending on the specific formulation and manufacturer. Patients are often instructed to use a pre-filled syringe or an auto-injector device provided with the medication. Before self-administering, patients should follow the instructions provided by their healthcare provider and the medication's package insert.Â
Safety Advices for Simponi 50mg Injection
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Pregnancy
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The safety of Simponi 50mg injection in pregnant women is not fully established, and its use during pregnancy requires consultation with a healthcare provider.
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Breast Feeding
 ÂThe safety of using Simponi 50mg injection while breastfeeding is not well established, and its use during this period should be carefully considered in consultation with a healthcare provider.Â
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Lungs
  Individuals with pre-existing lung conditions, such as chronic obstructive pulmonary disease (COPD) or interstitial lung disease (ILD), may already be susceptible to respiratory infections. The use of Simponi 50mg injection in such patients should only be done after consultation with a healthcare provider.
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Liver
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Yes, Simponi 50mg injection can affect liver function. Regular monitoring of liver enzyme levels is typically recommended during treatment.
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Alcohol
 ÂBoth Simponi 50mg injection and alcohol can affect the liver. This medication is metabolized by the liver, and excessive alcohol consumption can also impact liver function. If an individual has liver conditions or takes other medications that affect the liver, the combined use could have a cumulative effect on liver health.
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Driving
  Simponi 50mg injection may cause side effects that can impair driving ability and overall alertness. Common side effects include dizziness, headache, and tremors, affecting coordination and reaction time.
Side Effects of Simponi 50mg Injection
Simponi 50mg injection causes some side effects like all medications, although not everyone will experience them.Â
Serious
- Allergic reactions
- Elevated liver enzymes
- Blood disorders
- Immunosupression
Common
- Injection site reactions (pain, redness, swelling)
- Upper respiratory tract infections (e.g., common cold)
- Headache
- Elevated liver enzymes
- Nausea
- Rash or skin reactions
- Upper abdominal pain
- Sinusitis
- Urinary tract infections
Word of Advice
When considering the use of Simponi 50mg injection, it is important to make sure not having any infections before initiation of treatment. Regular monitoring of liver function and blood counts is required during treatemnt. Patients with heart failure, neurological disorders, or a history of malignancies, or require live vaccines, should tell a doctor before starting the treatment. People should be vigilant for any allergic reactions toward medication, Close monitoring is required in pediatric and geriatric patients for specific risks and benefits. Patients should communicate openly with healthcare providers about medical history, medications, and concerns to ensure informed decision-making and safe treatment.
FAQs
Q 1. Is regular monitoring necessary while on Simponi 50mg injection?
Regularly monitoring various health parameters, including liver function and blood tests, is typically recommended while using Simponi 50mg injection.
Q 2. What should I do if I experience side effects or allergic reactions Simponi 50mg injection?
If you experience severe side effects or allergic reactions, seek medical attention immediately and inform your healthcare provider.
Q 3. What are the serious infections that Simponi 50mg injection can increase the risk of?
Simponi 50mg injection can increase the risk of serious bacterial, viral, fungal, and tuberculosis (TB) infections. It's important to be vigilant for signs of infection and report them to your healthcare provider.
Q 4. How is tuberculosis (TB) risk managed while on Simponi 50mg injection?
Before starting Simponi 50mg injection, individuals are usually screened for latent TB infection. If latent TB is detected, it's often treated before starting it.
Q 5. Can Simponi 50mg injection worsen heart failure symptoms?
Simponi 50mg injection may worsen heart failure symptoms in individuals with a history of heart failure. Close monitoring is important in these cases.
Q 6. Does Simponi 50mg injection increase the risk of malignancies?
There may be a slightly increased risk of certain malignancies, including lymphoma. Discuss your individual risk factors with your healthcare provider.
Fact Box of Simponi 50mg Injection
Molecule name: Golimumab  | Therapeutic class: Immunomodulatory Agents |
Pharmacological class:Â Tumor Necrosis Factor (TNF) Inhibitors | Indications:Â 1. Rheumatoid arthritis 2. Psoriatic arthritis 3. Ankylosing spondylitis 4. Axial spondyloarthritis 5. Ulcerative colitis 6. Juvenile idiopathic arthritis |
References
- Janssen Biologics BV, Electronic medicines compendium (emc), [Revised on Oct 2020] [Accessed on 25th August 2023], https://www.medicines.org.uk/emc/files/pil.5707.pdf
- Janssen Biotech, US Food and Drug Administration, [Revised on August 2011] [Accessed on 25th August 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/125289s0064lbl.pdf
- Eleftherios Pelechas eta l; golimumab for Rheumatoid Arthritis; Journal of Clinical Medicine; [Published on March 2019]; [Accessed on 25/08/2023]; http://www.ncbi.nlm.nih.gov/pmc/articles/pmc6463251/
Disclaimer
MrMed’s primary intention is to ensure that its consumers get information that is reviewed by experts, accurate and trustworthy. The information and contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on MrMed. Our mission is to support, not replace, the doctor-patient relationship.
