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Terifrac 750mcg Injection
Prescription Required
Salt Composition : Teriparatide
Manufacturer : INTAS PHARMACEUTICALS LTD
Origin of Medicine : India
1 Cartridge(s)
Introduction to Terifrac 750mcg Injection
Terifrac 750mcg injection contains the active component as Teriparatide. Terifrac 750mcg injection, a synthetic version of parathyroid hormone (PTH) produced by the parathyroid glands, is employed for treating osteoporosis. Osteoporosis is a condition marked by weakened bones, heightening the likelihood of fractures. Fractures caused by osteoporosis can severely affect an individual's quality of life, causing pain and restricting mobility. Terifrac 750mcg injection functions by promoting the creation of new bone tissue and enhancing bone mineral density. This medication has been shown to accelerate bone healing in individuals with fractures. It promotes the formation of callus, the initial bridge of new bone that forms during the healing process, leading to faster and more efficient recovery.
Individuals who have a known hypersensitivity or allergic reaction to Terifrac 750mcg injection or any of its components should not use this medication. It is contraindicated in individuals with a history of skeletal malignancies, such as osteosarcoma, or those with bone metastases. If an individual has received prior radiation therapy involving the skeleton, the use of this medication is not advised due to the potential risk of osteosarcoma development.
Uses of Terifrac 750mcg Injection
- Postmenopausal osteoporosis
- Glucocorticoid-induced osteoporosis
Therapeutic Effects of Terifrac 750mcg Injection
Terifrac 750mcg injection, exerts a therapeutic effect by stimulating the formation of new bone tissue and increasing bone mineral density. By activating osteoblasts, the cells responsible for bone formation, it enhances bone strength, reduces fracture risk, and promotes bone healing. It offers significant benefits such as increased bone density, fracture risk reduction, improved quality of life, and serves as an alternative for individuals who have not responded well to other osteoporosis treatments.
Interaction of Terifrac 750mcg Injection with other drugs
Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with the Terifrac 750mcg injection, reducing effectiveness by causing undesirable side effects.
More Information about Terifrac 750mcg Injection
- Stored at controlled temperature, between 2-8°C.
- Keep away from moisture, heat, and light.
- It should not be frozen.
- Keep away from children and pets.
How to consume Terifrac 750mcg Injection
Terifrac 750mcg injection is typically administered by a healthcare professional. It is usually given as an injection. The healthcare provider will determine the dosage and duration of treatment based on the specific infection and individual factors.
Safety Advices for Terifrac 750mcg Injection
Pregnancy
The safety of Terifrac 750mcg injection use during pregnancy has not been established. If you are pregnant or planning to become pregnant, discussing the potential risks and benefits with your healthcare professional is essential.
Breast Feeding
Women should consult a doctor while breastfeeding while taking the Terifrac 750mcg injection.
Lungs
Suppose you have a pre-existing lung condition or are concerned about the safety of the Terifrac 750mcg injection in your lungs. Consulting with your healthcare provider for personalized advice is recommended in that case.
Liver
If you have a liver condition or are concerned about the safety of Terifrac 750mcg injection, it is recommended to consult your healthcare provider for personalized advice.
Alcohol
It is generally advisable to avoid consuming alcohol while taking Terifrac 750mcg injection. Alcohol can impair the body's immune system, making it less effective in fighting infections.
Driving
People may experience side effects, including dizziness, drowsiness, or fatigue, after using Terifrac 750mcg injection. In that case, avoid driving or operating heavy machinery.
Side Effects of Terifrac 750mcg Injection
Terifrac 750mcg injection cause some side effects like all medications, although not everyone will experience them.
Serious:
- Hypercalcemia
- Allergic reactions that affect skin and breathing
- Skin reactions at the injection site include rashes, bruising, swelling, and itching
- Osteosarcoma (type of bone cancer)
- Hypercalcemia (increased level of calcium)
- Orthostatic hypotension (hypertension when stand after sitting or lying position)
Common:
- Arthralgia
- Nerve Pain
- Nausea
- Sickness
- Headache
- Dizziness
- Increased sweating
- Breathlessness
- Muscle cramps
- Increase in blood cholesterol levels
- Chest pain
- Burning sensation below the breast bone
- Anaemia
Word of Advice
Prior to initiating Terifrac 750mcg injection, it is crucial to disclose any preexisting medical conditions, particularly those related to bones or metabolism, as well as provide information about any medications or supplements being taken, to your healthcare professional. Extra care should be taken for individuals with a history of skeletal malignancies or bone metastases, as Terifrac 750mcg injection is not recommended in such cases.
Regular monitoring of serum calcium levels is essential to identify and manage hypercalcemia. In patients with orthostatic hypotension or pre-existing hyperparathyroidism, Terifrac 750mcg injection should be used cautiously. The duration of treatment with this medication is generally limited, and its use is not advised in pediatric patients. If you are pregnant or breastfeeding, discussing the potential risks and benefits of Terifrac 750mcg injection with your healthcare provider before considering its use is crucial.
FAQs
Q 1. Can Terifrac 750mcg injection be used in individuals with a history of cancer?
Terifrac 750mcg injection is generally not recommended for individuals with a history of cancer, especially skeletal malignancies or bone metastases. The medication has been associated with an increased risk of osteosarcoma, and its safety in individuals with a history of cancer has not been well established.
Q 2. Can Terifrac 750mcg injection be used in men with osteoporosis?
Yes, Terifrac 750mcg injection can be used in men with osteoporosis. While osteoporosis is more commonly associated with women, men can also develop the condition. It can effectively increase bone density and reduce fracture risk in men with osteoporosis.
Q 3. Can Terifrac 750mcg injection be used in individuals with a history of kidney disease?
Terifrac 750mcg injection does not undergo significant renal excretion so it can be used in individuals with mild to moderate kidney impairment. However, caution is advised in individuals with severe kidney disease, as there is limited data on the safety and effectiveness of this medication in this population.
Q 4. Can Terifrac 750mcg injection be used in individuals with a history of fractures?
Terifrac 750mcg injection is commonly prescribed for individuals with a history of fragility fractures. Fragility fractures occur due to minimal trauma or impact and are often associated with osteoporosis. It helps to increase bone density and reduce the risk of future fractures in individuals with osteoporosis, including those who have previously experienced fractures.
Q 5. Can Terifrac 750mcg injection be used as a first-line treatment for osteoporosis?
Terifrac 750mcg injection is typically not used as a first-line treatment for osteoporosis. It is usually considered when other osteoporosis medications are ineffective, or individuals have a high fracture risk. However, whether it is appropriate as a first-line treatment depends on individual factors and should be discussed with your healthcare provider.
Q 6. What are the potential long-term effects of Terifrac 750mcg injection?
The long-term effects of Terifrac 750mcg injection have yet to be well understood, particularly beyond the recommended treatment duration of 2 years. The risk of osteosarcoma, a potential rare side effect, is one of the main concerns associated with long-term use.
Q 7. What are the side effects of Terifrac 750mcg injection?
Terifrac 750mcg injection may cause side effects, including common ones such as injection site reactions, nausea, dizziness, and headache. Serious side effects, though rare, can include the development of osteosarcoma, a type of bone cancer, and the potential for hypercalcemia, which can lead to symptoms like excessive thirst and muscle weakness.
Fact Box of Terifrac 750mcg Injection
Molecule name: Teriparatide | Therapeutic class: Bone formation stimulator |
Pharmacological class: Parathyroid hormone analogs | Indications: 1. Postmenopausal osteoporosis 2. Glucocorticoid-induced osteoporosis |
References
- Eli Lilly and Company Limited, Electronic medicines compendium (EMC), [Revised on 06 Feb 2023], [Accessed on 1st June 2023], https://www.medicines.org.uk/emc/files/pil.3634.pdf
- Eli Lilly and Company, US Food and Drug Administration, [Revised on September 2021],[Accessed on 1st June 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/021318Orig1s056lbl.pdf
- KD Tripathi, Hormones and Drugs Affecting Calcium Balance, Essentials of Medical Pharmacology, 8th Edition, 2019, 360-372
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