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- Reviewed By
- Dr. Tejashwin Adiga
- MBBS
Last updated Mon, 24 Feb 2025 13:49 UTC
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Tubervac Injection
Prescription Required
Salt Composition : Bacillus Calmette-guerin Strain
Manufacturer : SERUM INSTITUTE OF INDIA
Origin of Medicine : India
1 Vial(s)
Introduction to Tubervac Injection
Tubervac Injection contains the active ingredient Bacillus calmette-guerin strain. It is an anticancer drug that belongs to the class of medications called vaccines. It is used to treat bladder cancer (a type of cancer that starts in the cells of the bladder, which is a hollow organ located in the lower abdomen).
Do not take Tubervac Injection if you are allergic to it or any other ingredients of this medicine. Report to your physician if you face any symptoms of sudden difficulty in breathing, fever, redness or flushing of the skin, or a rash, nausea, or vomiting after the administration of the injection.
Tubervac Injection is not recommended for children and young people under 18 years of age. Use an effective method of contraception while being treated with this injection. Avoid pregnancy and breastfeeding during the treatment, as it can cause harm to the foetus.
Tubervac Injection is contraindicated in individuals with a weakened immune system. It is a live bacteria and can potentially cause infections in people with weakened immune systems, such as those with HIV and cancer or who are receiving immunosuppressive therapy.
Tubervac Injection may not be recommended for individuals who have a history of tuberculosis, as it may not be effective in preventing a new infection or may interfere with the diagnosis of a new infection.
Uses of Tubervac Injection
Tubervac Injection is used in the treatment of the following:
- Bladder cancer
Therapeutic Effects of Tubervac Injection
Tubervac Injection works by stimulating the immune system of the body to attack the cancer cells lining the bladder. When the injection is administered directly into the bladder, it activates the cells in the immune system to produce an immune response against the cancer cells, which helps to destroy them.
Interaction of Tubervac Injection with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, vaccines, nutritional and vitamin supplements, and herbal products. Certain medications may interact with Tubervac Injection and reduce its effectiveness by causing undesirable side effects.
More Information about Tubervac Injection
- Store Tubervac Injection in the refrigerator (2°C to 8°C)
- Do not freeze
- Keep the injection away from the reach of children and pets.
- If you have missed any dosing appointments, inform your doctor and schedule immediately.
How to consume Tubervac Injection
It will be given to you by a doctor or nurse in a hospital or clinic setting trained in cancer chemotherapy. The Tubervac Injection is usually given as an intravesical injection which is administered directly into the bladder through a catheter by your doctor. Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity, body weight, and other factors.
Safety Advices for Tubervac Injection
Pregnancy
Tubervac Injection is unsafe to administer in pregnant women because it may affect the fetus. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant. Using an effective birth control method during the treatment and for 3 months after your last dose is necessary.
Breast Feeding
Breastfeeding is not recommended in patients taking Tubervac Injection because the medicine passes into the breast milk in small amounts and may harm your baby.
Lungs
It is unknown whether Tubervac Injection can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.
Liver
Tubervac Injection is unsafe to use in patients with liver diseases. Dose adjustments are necessary. Inform your physician if you have any liver problems before initiating the therapy.
Alcohol
It is unsafe to consume alcohol with Tubervac Injection because alcohol may reduce the effectiveness of the medicine.
Driving
It is unsafe to drive or operate heavy machinery after taking Tubervac Injection. The medicine may make you feel dizzy or tired.
Side Effects of Tubervac Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Common side effects of Tubervac Injection are:
- Frequency and urgency of urination, painful urination
- Inflammation of bladder
- Urinary tract infection
- Fever
Word of Advice
If you are planning to receive any vaccines, including the yellow fever vaccine, you should inform your doctor and discuss the risks and benefits of receiving the vaccine while undergoing treatment with Tubervac Injection. This injection may cause UTIs, so it is necessary to maintain good hygiene and to drink plenty of fluids during the treatment to prevent urinary tract infections.
FAQs
Q 1. Whether Tubervac Injection be given at home?
A healthcare professional usually administers Tubervac Injection in a hospital or clinic setting. This is because of the Tubervac Injection is injected directly into the bladder, which requires special training and equipment to perform safely and effectively. However, in some cases, it may be possible for patients to receive Bacillus calmette-guerin strain at home with the support of a healthcare professional.
Q 2. Will I get a fever after receiving the Tubervac Injection?
Yes, some people may get a mild to moderate fever, and usually, it goes away on their own within a few days. If you experience a fever or other side effects that persist or become more severe over time, you should contact your healthcare provider.
Q 3. Can Tubervac Injection be given to patients with kidney problems?
Tubervac Injection is primarily excreted through the kidneys, so patients with kidney problems may be at increased risk of side effects from the drug. Inform your physician if you have kidney problems before initiating the therapy.
Q 4. How is Tubervac Injection administered?
Tubervac Injection is administered through intravesical injection, which means it is injected directly into the bladder through a catheter that is inserted through the urethra. The medication is then held in the bladder for a period of time before being expelled through urination.
Q 5. Can Tubervac Injection cause Urinary tract infections?
Yes, Tubervac Injection can cause urinary tract infections like bladder irritation, frequent urination and blood in the urine. If you face any symptoms, inform your doctor immediately and seek medical advice.
Fact Box of Tubervac Injection
Molecule name: Bacillus calmette-guerin strain | Therapeutic class: Anticancer |
Pharmacological class: Vaccines | Indications: Bladder cancer |
References
- Ciplamed, [Published on 16/08/2017] (Accessed: 29 April 2023), https://5.imimg.com/data5/BJ/HT/LM/SELLER-4164638/sii-onco-bcg-injection.pdf
- Dominic H Tang, Sam S Chang; Management of carcinoma in situ of the bladder: best practice and recent developments; Therapeutic Advances in Urology; Published on Dec 2015;(Accessed: 29 April 2023); https://www.ncbi.nlm.nih.gov/pubmed/26622320
- Pettenati C, Ingersoll MA, Mechanisms of BCG immunotherapy and its outlook for bladder cancer; Natural Reviews, Urology; Published on Oct 2018;(Accessed: 29 April 2023); https://pubmed.ncbi.nlm.nih.gov/29991725/
- Onco-BCG Injection (BCG for immunotherapy I.P - freeze-dried). Available at: https://5.imimg.com/data5/BJ/HT/LM/SELLER-4164638/sii-onco-bcg-injection.pdf (Accessed: 29 April 2023).
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Immunosuppressants, Tolerogens, and Immunostimulants, 12th edition, 2011, 1022.
- KD Tripathi, Essentials of Medical Pharmacology, Vaccines and sera, 7th edition, 2013, 922.
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