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Ustekirel 45mg Injection
Prescription Required
Salt Composition : Ustekinumab
Manufacturer : RELIANCE LIFE SCIENCES PVT LTD
Origin of Medicine : India
1 Vial(s)
Introduction to Ustekirel 45mg Injection
Ustekirel 45mg Injection contains the active substance Ustekinumab. It is a monoclonal antibody that belongs to the group of medications called interleukin inhibitors. Monoclonal antibodies are specific proteins that identify and bind to certain proteins in the body. It treats moderate to severe plaque psoriasis (skin disease with red and scaly patches on some body areas). It is used alone or in combination with other medicines to treat active psoriatic arthritis (a condition that causes joint pain, swelling, and scales on the skin) in adults.
Ustekirel 45mg Injection is also indicated to treat moderate to severe Crohn’s disease and ulcerative colitis in adults. Both are inflammatory bowel diseases. Crohn’s disease is a condition in which the body attacks the lining of the digestive tract, causing abdominal pain, diarrhoea, weight loss, and fever. Ulcerative colitis is a condition that causes swelling and sores in the lining of the colon (large intestine) and rectum. Do not use this medicine if you are pregnant or breastfeeding.
Do not take Ustekirel 45mg Injection if you are allergic to Ustekinumab or any of the other ingredients of this medicine. Do not take this medicine if you have any active infections. Inform your doctor if you recently had tuberculosis, skin diseases, allergies, or other diseases. Tell your doctor if you are taking other treatments for psoriasis or psoriatic arthritis. This medicine is not recommended for use in children under 18 years of age with Crohn’s disease or ulcerative colitis.
Uses of Ustekirel 45mg Injection
- Plaque psoriasis
- Psoriatic arthritis
- Crohn’s disease
- Ulcerative colitis
Therapeutic Effects of Ustekirel 45mg Injection
Ustekirel 45mg Injection is a monoclonal antibody that binds specifically to certain signalling proteins (interleukin-12 and interleukin-23) in the body, which is involved in inflammatory and immune responses. It works by targeting, neutralising, and stopping the action of certain cells in the body that cause the symptoms of certain diseases.
Interaction of Ustekirel 45mg Injection with other drugs
Inform your healthcare provider about all the medicines that you take, including prescription, over-the-counter, recent vaccinations, nutritional and vitamin supplements, and herbal products. Certain medications may interact with Ustekirel 45mg Injection and reduce its effectiveness by causing undesirable side effects.
More Information about Ustekirel 45mg Injection
- Store Ustekirel 45mg Injection in the refrigerator (2°C to 8°C)
- Do not freeze
- keep the injection away from the reach of children and pets.
- Do not shake the vials because prolonged shaking may damage the effectiveness of the medicine.
How to consume Ustekirel 45mg Injection
It will be given to you by a doctor or nurse in a hospital or clinic setting. It is given as an intravenous infusion (into your vein). Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity, body weight, and other factors.
Safety Advices for Ustekirel 45mg Injection
Pregnancy
Ustekirel 45mg Injection is unsafe to administer in pregnant women because it may affect the fetus. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant. Using effective contraception during the treatment and for at least 15 weeks after your last dose is necessary.
Breast Feeding
Breastfeeding is not recommended in patients taking Ustekirel 45mg Injection because the medicine passes into the breast milk in small amounts and may harm your baby.
Lungs
It is unknown whether Ustekirel 45mg Injection can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.
Liver
It is unknown whether Ustekirel 45mg Injection can be used in patients with liver disorders. Consult your doctor if you have any liver problems before starting the treatment.
Alcohol
It is unknown whether consuming alcohol is safe during the treatment with Ustekirel 45mg Injection. Inform your doctor if you are a chronic drinker.
Driving
Ustekirel 45mg Injection does not affect the ability to drive. If you feel tired or dizzy after taking this medicine, do not drive and consult your doctor for more advice.
Side Effects of Ustekirel 45mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Common
- Swelling at the site of injection
- Redness in the skin
- Abdominal pain
- Diarrhea
- Nausea, vomiting
- Tiredness, headache
- Sore throat
- Back, muscle or joint pain
Serious
- Severe allergic reactions (anaphylaxis)
- Skin cancer
- Infections
- Lung inflammation and infection
- Heart attack
Word of Advice
If you have missed any dosing appointments, inform your doctor and schedule immediately. Ustekirel 45mg Injection may increase your risk for heart attack and strokes. Your doctor will regularly check your risk factors for heart disease and stroke to ensure that they are appropriately prevented. If you develop chest pain, weakness, or abnormal sensation on one side of your body, facial droop, or visual or speech difficulties, seek medical attention immediately. If you are a female patient with reproductive potential, use effective contraception during the treatment to avoid pregnancy.
FAQs
Q 1. What are the infusion reactions that might happen during a Ustekirel 45mg Injection?
Serious side effects of Ustekirel 45mg Injection are allergic reactions like itching, swelling in your face or hands, tingling in mouth or throat, chest tightness, difficulty in breathing, fever, chills, cough, sore throat, body aches, unusual bleeding, bruising, or weakness should be informed to your doctor immediately.
Q 2. How does Ustekirel 45mg Injection work?
Ustekirel 45mg Injection mechanism of action targets specific proteins in the body's immune system called interleukin-12 (IL-12) and interleukin-23 (IL-23) cytokines (signalling proteins). By blocking these proteins, this medicine helps reduce the inflammation associated with autoimmune conditions and other diseases.
Q 3. How long does it take for Ustekirel 45mg Injection to start working?
The response to Ustekirel 45mg Injection can vary from person to person. Some individuals may start to see improvements in their symptoms within a few weeks, while others may require a longer time to notice a difference. If you did not find any benefit from the medicine, inform your physician and get medical advice.
Q 4. How long can Ustekirel 45mg Injection be taken?
The duration of Ustekinumab.NPP treatment can vary depending on the individual factors and the response to the medication. Some individuals may require long-term treatment to manage their condition effectively, while others may have periodic treatment cycles. It's essential to follow your doctor's guidance regarding the duration of treatment.
Q 5. Can Ustekirel 45mg Injection increase the risk of infections?
Ustekirel 45mg Injection may increase the risk of infections and reactivation of latent infections, including serious infections. It's important to promptly report any signs of infection to your healthcare provider, such as fever, cough, or flu-like symptoms. Your healthcare provider will monitor your health and provide guidance on managing potential risks.
Fact Box of Ustekirel 45mg Injection
| Molecule name: Ustekinumab | Therapeutic class: Immunomodulating agents |
| Pharmacological class: Monoclonal antibody; interleukin inhibitor | Indications: 1. Plaque psoriasis 2. Psoriatic arthritis 3. Crohn’s disease 4. Ulcerative colitis |
References
- Janssen Biologics B.V., Electronic medicines compendium (EMC), [Revised on March 2023] [Accessed on 21 June 2023] https://www.medicines.org.uk/emc/files/pil.4412.pdf
- Janssen Biotech, Inc., US Food and Drug Administration [Revised on September 2016] [Accessed on 21 June 2023] https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/761044lbl.pdf
- Cite this Page Colquhoun M, Kemp AK. Ustekinumab. [Updated 2023 Mar 27]. In: StatPearls. Treasure Island (FL): StatPearls Publishing; [Accessed on June 2023] https://www.ncbi.nlm.nih.gov/books/NBK570645/
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