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Vaptan 15mg Tablet
Prescription Required
Salt Composition : Tolvaptan
Manufacturer : STEADFAST MEDISHIELD PVT LTD
Origin of Medicine : India
7 Tablet(s) In A Strip
Introduction to Vaptan 15mg Tablet
Vaptan 15mg Tablet contains an active component called Tolvaptan. It belongs to a class of Vasopressin antagonists. The medicine increases the excretion of water in the urine, which increases aquaresis (water excretion without loss of electrolyte) and decreases the osmolarity of urine (measurement of urine concentration), increasing serum sodium concentration. This medicine needs close monitoring of blood sodium levels. Patients are advised to take enough water during the treatment to avoid dehydration. Those who are restricted are recommended to consult the healthcare provider.  Â
Before starting the treatment, consult your doctor if you have kidney and liver disorders or are allergic to ingredients such as benzazepine, tolvaptan, or other benzazepine derivatives. This medicine is contraindicated to patients with Anuria (lack of urine), Hypovolemic hyponatremia (Deficiency in both total body water and sodium level), Hypernatremia (high sodium level in blood), and patients who cannot feel thirst. So, it is recommended that you discuss your medical history with your doctor. The safety and efficacy of children below 18 years old are unknown; hence, consult your doctor before giving the medicine to children. Â
Uses of Vaptan 15mg Tablet
- Hyponatremia (Low sodium levels in the blood)
- Autosomal dominant polycystic kidney disease [ADPKD]
Therapeutic Effects of Vaptan 15mg Tablet
Tolvaptan blocks the vasopressin hormone effect (antidiuretic hormone- that helps to prevent water loss), decreases the amount of water in your body by increasing urine production, and, as a result, raises the concentration of sodium in your blood.
Interaction of Vaptan 15mg Tablet with other drugs
Inform your doctor including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Vaptan 15mg Tablet, reducing effectiveness by causing undesirable side effects.Â
Inform your doctor if you have taken ketoconazole (against fungal infections), macrolide antibiotics, diltiazem (treatment for high blood pressure and chest pain), digoxin (used for treatment of irregularities of heartbeat and heart failure), dabigatran etexilate (used to thin the blood), metformin (used to treat diabetes), sulfasalazine (used to treat inflammatory bowel disease or rheumatoid arthritis) it may increase the effect the drug whereas, drug-like barbiturates (used to treat epilepsy/seizures and some sleep disorders), rifampicin (against tuberculosis) and desmopressin may decrease the effect of the medicine. Avoid drinking grapefruit juice before or after the medication. It may interact with the drug.
More Information about Vaptan 15mg Tablet
- Protect from light and moisture
- Store at 25ËšC
- Keep children away from the sight and reach of this medication.
How to consume Vaptan 15mg Tablet
Take a Vaptan 15mg Tablet exactly as directed by your doctor. Your doctor will provide the appropriate dose and frequency based on your medical condition and other factors. Do not crush or chew the tablets. Swallow the tablets whole with water. Have plenty of water and contact your doctor immediately. If you have taken an excess tablet than the prescribed dosage, don't double up the medicine if you forgot to take the medicine.
Safety Advices for Vaptan 15mg Tablet
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Pregnancy
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It is unknown whether Vaptan 15mg tablets are harmful to the unborn baby. Notify your healthcare professional if you are pregnant or planning to have a baby think you may be pregnant.Â
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Breast Feeding
 ÂIt is unknown whether Vaptan 15mg Tablet is excreted in breast milk. So, before starting the treatment, inform your doctor if you are breastfeeding. Consult your doctor for more information.Â
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Lungs
  It is unknown whether Vaptan 15mg Tablet is safe for patients with lung problems. Inform your physician if you have any lung disease before starting the treatment. Contact your doctor if you experience any lung-related symptoms.
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Liver
  It is unknown whether Vaptan 15mg Tablet is safe for patients with liver problems. Notify your physician if you have any liver disease before starting the treatment. Contact your doctor if you experience any liver-related symptoms.
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Alcohol
 ÂIt is unknown whether consuming alcohol while taking a Vaptan 15mg Tablet is safe. Please speak with your physician.
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Driving
  It is unknown whether Vaptan 15mg Tablet alters driving ability. However, if you experience side effects like tiredness or drowsiness, avoid driving and using machines.Â
Side Effects of Vaptan 15mg Tablet
Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.
Serious
- Feeling difficulty in urination
- Allergic reaction (swelling in the face, lips, or tongue, itching, or severe wheezing or breathlessness)
Common
- Feeling sick
- Thirst
- A rapid rise in the level of sodium.
- Excessive drinking of water
- Water loss
- High levels of sodium, potassium, creatinine, uric acid, and blood sugar
- Decrease in level of blood sugar
- Decreased appetite
- Fainting
- Headache
- Dizziness
- Low blood pressure when standing up
- Constipation
- Diarrhea
- Dry mouth
- Patchy bleeding in the skin
- Itching
- Frequent urination
- Tiredness, general weakness
- Fever
- Blood in urine
- Elevation of liver enzyme in the blood
- Raised levels of creatinine in the blood.
Word of Advice
Consult your doctor if you have diabetes, liver, or kidney problems before starting the medicine. Drink plenty of water to overcome the water loss, and don't drink grape juice while under medication. Consult your doctor if you have lactose intolerance because the drug contains lactose. Inform your doctor if you can’t feel a sense of thirst. Individuals are advised to monitor their blood sodium levels to avoid undesirable side effects. Inform your doctor if you have the following symptoms: fatigue, loss of appetite, right upper abdominal discomfort, dark urine, or jaundice.
FAQs
Q 1. Can I take a Vaptan 15mg Tablet during diabetes?
Inform your doctor if you have diabetes because the drug may cause hyperglycemia in the patient. So, it is recommended to be cautious while taking the medicine.
Q 2. What medicines must we avoid while taking Vaptan 15mg Tablet?
Drugs like ketoconazole (against fungal infections), macrolide antibiotics, diltiazem (high blood pressure and chest pain treatment), digoxin (used for the treatment of irregularities of heartbeat and heart failure), dabigatran etexilate (used to thin the blood), metformin (used to treat diabetes), sulfasalazine ( inflammatory bowel disease or rheumatoid arthritis), barbiturates (used to treat epilepsy/seizures and some sleep disorders), rifampicin (against tuberculosis) and desmopressin may alter the drug action. So, discussing your prescribed and non-prescribed medicine with your doctor is recommended.
Q 3. Does Vaptan 15mg Tablet cause high blood pressure?
No, Tolvapan doesn't cause high blood pressure. There is no clinical evidence for the drug's action with the blood pressure.
Q 4. Do I experience fatigue or dizziness while taking the Vaptan 15mg Tablet?
The drug may cause side effects like dizziness, fainting, or weakness for a short period. Please inform your doctor about the side effects, and it is recommended to avoid driving under medication.
Q 5. What are the foods I need to avoid?
Drinking grape juice before or after taking the medicine may interact with Vaptan 15mg Tablet. So, it is recommended to avoid it.
Fact Box of Vaptan 15mg Tablet
Molecule name: Tolvaptan | Therapeutic class: Lower blood sodium level |
Pharmacological class: Vasopressin antagonists | Indications: Hyponatremia (Low sodium levels in the blood) |
References
- Otsuka Pharmaceutical Netherlands BV, Electronic medicines compendium (EMC), [Revised on Jan 2020], [Accessed on 21st Sep 2023] https://www.ema.europa.eu/en/documents/product-information/samsca-epar-product-information_en.pdf
- Otsuka Pharmaceutical Co., Ltd, US Food and Drug Administration, [Revised on April 2013] https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/022275s009lbl.pdf
- KD Tripathi, Essentials of Medical Pharmacology, Adrenergic system and drugs, 7th edition, 2013, 134.
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Blood coagulation and anticoagulant, fibrinolytic, and antiplatelet drugs, 12th edition, 2011, 866.
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