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Xeljanz 5mg Tablet
Prescription Required
Salt Composition : Tofacitinib
Manufacturer : PFIZER LTD
Origin of Medicine : United States of America
60 Tablet(s) In A Bottle
Introduction to Xeljanz 5mg Tablet
Xeljanz 5mg tablet contains the active substance Tofacitinib. It is a disease-modifying anti-rheumatoid drug (DMARDs) that belongs to the class immunomodulators. It is used alone or with other medications to treat rheumatoid arthritis (A condition in which the body attacks its joints, causing pain, swelling, and loss of function) in adults who are unable to take or do not respond to other medications. It is also used to treat psoriatic arthritis (A condition that causes joint pain and swelling, and scales on the skin). It is also indicated for treating adult patients with moderately to severely active ulcerative colitis. Â
Other uses of Xeljanz 5mg tablet include ankylosing spondylitis (inflammatory disease of the spine). It is also used to treat active polyarticular juvenile idiopathic arthritis, a long-term disease mainly causes pain and swelling of your joints in patients 2 years of age and older. The medicine works by decreasing the activity of the immune system. Inform your physician if you have a severe blood infection, active tuberculosis, and liver problems. Notify your doctor if you ever had or have a hepatitis B infection because this medicine could cause the hepatitis B to become active again. Â Â
Do not take Xeljanz 5mg tablet if you are allergic to tofacitinib or any other ingredients of this medicine. Inform your healthcare professional if you have any symptoms of an infection, such as fever, sweating, chills, muscle aches, cough, shortness of breath, weight loss, skin sores, difficulty or pain when swallowing, diarrhea, or stomach pain. Before initiating the treatment, inform your physician if you have kidney, heart, lung, or liver problems, a history of tuberculosis, high blood pressure, or high cholesterol, and also if you are a current or past smoker.
Uses of Xeljanz 5mg Tablet
- Rheumatoid arthritis
- Psoriatic arthritis
- Ankylosing spondylitis
- Ulcerative colitis
- Polyarticular juvenile idiopathic arthritis
- Juvenile psoriatic arthritis
Therapeutic Effects of Xeljanz 5mg Tablet
Tofacitinib in Xeljanz 5mg tablet is a disease-modifying anti-rheumatic drug (DMARD) in the category of Janus Kinase Inhibitors. Janus kinase is a type of enzyme (tyrosine kinase)Â involved in the signalling of cytokine receptors. It works by inhibiting Janus kinases and interferes with the transcription of genes involved in cell growth and differentiation.
Interaction of Xeljanz 5mg Tablet with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, vaccinations, nutritional and vitamin supplements, and herbal products. Certain medications may interact with the effects of Xeljanz 5mg tablet and reduce its effectiveness by causing undesirable side effects.
More Information about Xeljanz 5mg Tablet
- Store Xeljanz 5mg tablet at room temperature (20°C to 25°C)
- keep the tablet away from the reach of children and pets.
- If you forgot to take a dose, take it as soon as you remember. However, if it is nearly time for the next dose, skip the missed dose.
- Do not take a double dose to make up for a forgotten dose.
How to consume Xeljanz 5mg Tablet
Your doctor will decide the dose and duration of the treatment based on your disease condition, severity, and other factors. Take the tablets as prescribed by your doctor. Do not break, crush, or chew the tablets. Swallow the tablet whole with a glass of water. Take the tablet with or without food.
Safety Advices for Xeljanz 5mg Tablet
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Pregnancy
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Xeljanz 5mg tablet is unsafe to administer in pregnant women because it may affect the fetus. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant. Using an effective birth control method during the treatment and for at least 4 weeks after your last dose is necessary. Â
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Breast Feeding
 ÂBreastfeeding is not recommended in patients taking Xeljanz 5mg tablet because the medicine passes into the breast milk in small amounts and may harm your baby.Â
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Lungs
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It is unknown whether Xeljanz 5mg tablet can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.
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Liver
  Xeljanz 5mg tablet is unsafe when administered in patients with severe liver diseases. Dose adjustments are necessary in severe liver failure. Inform your physician if you have liver problems before initiating the therapy. Â
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Alcohol
 ÂIt is unknown whether it is safe to consume alcohol when taking Xeljanz 5mg tablet. Consult your doctor for more advice.
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Driving
  The drug has no or limited effect on your ability to drive or operate heavy machines. If you face any difficulties, consult your doctor for more advice.
Side Effects of Xeljanz 5mg Tablet
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.Â
 Common
- Increased cholesterol levels
- Headache
- Painful urination
- Inflammation of the nose
- Cough
- Shortness of breath
- Diarrhea
- Skin rashesÂ
SeriousÂ
- Lung cancer
- White blood cell cancer
- Heart attack
- Fever and chills
- Blood in the stool
- Stomach pain or abdominal pain
- Skin blisters
Word of Advice
This medicine may interfere with vaccines, inform your physician about your vaccination history. This medicine may impair fertility; talk to your doctor before taking this medicine. Your doctor will regularly do lab tests to check whether the medicine is working. Do not breastfeed during the treatment with this medicine and for at least 36 hours after your last dose. This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury.
FAQs
Q 1. What are the cautions of Xeljanz 5mg tablet?
Tell your doctor immediately if you start to have swelling of your face, lips, tongue, throat, arms, or legs or if you are having trouble swallowing or breathing. Xeljanz 5mg tablet can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection.
Q 2. Does Xeljanz 5mg tablet cause high cholesterol?
Increased cholesterol levels are one of the side effects of Xeljanz 5mg tablet, your doctor may take regular blood tests to check for serious side effects.
Q 3. Can Xeljanz 5mg tablet cause depression?
No, Xeljanz 5mg tablet does not cause depression. However, many people who have autoimmune conditions also have symptoms of depression. If you're having symptoms of depression, see your doctor right away.
Q 4. Does Xeljanz 5mg tablet cause blood clots?
Yes, blood clots are reported in patients using Xeljanz 5mg tablet for a longer period. Inform your physician if you face any symptoms of a blood clot.
Q 5. How long does it take Xeljanz 5mg tablet to work?
Xeljanz 5mg tablet is a long-term treatment. Most people who benefit from this treatment will notice an improvement in the first 12 weeks of starting treatment.
Fact Box of Xeljanz 5mg Tablet
Molecule name: Tofacitinib  | Therapeutic class: Antirheumatoid |
Pharmacological class: Tyrosine kinase inhibitor | Indications: 1. Rheumatoid arthritis 2. Psoriatic arthritis 3. Ankylosing spondylitis 4. Ulcerative colitis 5. Polyarticular juvenile idiopathic arthritis 6. Juvenile psoriatic arthritis |
References
- XELJANZ 5 mg film-coated tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. www.medicines.org.uk. [cited 2023 Mar 25]. Available from: https://www.medicines.org.uk/emc/product/2500/smpc
- HIGHLIGHTS OF PRESCRIBING INFORMATION - Tofacitinib. [revised on 2018] [cited 2023 Mar 25]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/203214s018lbl.pdf
- ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS - Tofacitinib. [cited 2023 Mar 25]. Available from: https://www.ema.europa.eu/en/documents/product-information/xeljanz-epar-product-information_en.pdfÂ
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