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Xtandi 40mg Capsule
Prescription Required
Salt Composition : Enzalutamide
Manufacturer : ASTELLAS PHARMA INC
Origin of Medicine : India
112 Capsule(s) In A Bottle
Introduction to Xtandi 40mg Capsule
Xtandi 40mg capsule contains the active ingredient Enzalutamide. It is an antineoplastic drug that belongs to the category of medicines known as androgen receptor inhibitors. This medication is used in the treatment of advanced prostate cancer in patients who do not respond to surgical or hormonal treatments.
It is not recommended to take this capsules if you are allergic to any of its ingredients. During the treatment, your doctor may periodically monitor for Prostate-specific antigen (PSA) tests. This blood test measures the level of PSA, a protein produced by the prostate gland that can be elevated in men with prostate cancer. PSA levels can help monitor the progression of the disease and the response to treatment. Other tests also include liver function tests and complete blood count(CBC) to prevent serious complications.
This medicine can cause seizures, so patients with a history of seizures should use caution when taking this medication. Avoid grapefruit and grapefruit juice while taking this drug, as it can increase the levels of the medication in the body. This drug is not recommended during pregnancy as it causes harm to the unborn baby, and it also causes fertility issues, inform your doctor about any fertility concern you may have before starting treatment with this medicine. Before beginning this treatment, tell your healthcare provider if you are pregnant or planning to have a baby. It is advised for both men and women to follow proper contraceptive methods during and for 3 months after the last dose of Xtandi 40mg capsule.
Uses of Xtandi 40mg Capsule
- Advanced prostate cancer
Therapeutic Effects of Xtandi 40mg Capsule
It works by inhibiting the active form of testosterone, called dihydrotestosterone. It selectively blocks the androgen receptors and disrupts the translocation of signals from the receptor to the cell. Thus, the androgen hormone does not bind to the androgen receptors and these androgen receptors do not interact with DNA. This blocks the functioning of cancer cells and reduces its multiplication.
Interaction of Xtandi 40mg Capsule with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Xtandi 40mg capsule and reduce effectiveness by causing undesirable side effects.
More Information about Xtandi 40mg Capsule
- Store Xtandi 40mg capsule in the original package at room temperature (20°C to 25°C).
- Keep it out of reach from children and pets.
How to consume Xtandi 40mg Capsule
Your doctor will decide the dose and duration of Xtandi 40mg capsule based on the disease condition and other factors. Always take this medicine as prescribed by your doctor. The standard dose for this drug is 160 mg taken once daily, with or without food. Do not chew, crush, or break the capsule. Swallow the whole capsule with water. If you forgot to take the capsule, simply take your next dose at the scheduled time. Do not take a double dose to make up for a forgotten dose.
Safety Advices for Xtandi 40mg Capsule
Pregnancy
Xtandi 40mg capsule is not recommended for pregnant women as it may cause fetal harm. Consult your doctor if you are pregnant or planning for pregnancy during the treatment.
Breast Feeding
It is not known if Xtandi 40mg capsule passes into your breast milk or if it will affect your baby or your breast milk. Talk to your doctor about the best way to feed your baby if you receive this drug.
Lungs
It is not known whether Xtandi 40mg capsule can be prescribed to patients with lung problems. Consult your doctor if you have any lung diseases before starting the treatment.
Liver
Inform your doctor if you have any liver disorders before taking Xtandi 40mg capsule. Regular monitoring of liver function tests is recommended.
Alcohol
It is unknown whether consuming alcohol interacts with Xtandi 40mg capsule. Please consult your doctor for more advice.
Driving
Xtandi 40mg capsule may cause drowsiness which can affect the patient’s ability to drive or use machines.
Side Effects of Xtandi 40mg Capsule
Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.
Serious
- Hypersensitivity
- Seizures
- Posterior reversible encephalopathy syndrome
- Heart disease
- Falls and fractures
Common
- Tiredness
- Back pain
- Constipation
- Arthralgia
- Decreased appetite
- Diarrhea
- High BP
- Headache
- Anxiety
- Dry skin
- Enlarged breasts in men
- Inability to concentrate
Word of Advice
Xtandi 40mg capsule causes skin dryness so it is advised to use an effective moisturiser for your skin. Ensure that you stay hydrated and maintain a balanced diet. Store the drug in the original package at room temperature (25°C). Keep it out of reach from children and pets. It is important to get the dose at the scheduled time. If you missed the schedule, contact your doctor and reschedule the dose. Avoid driving or operating heavy machines if you experience dizziness, nausea, or tiredness while on treatment with this drug.
FAQs
Q 1. What tests are essential before starting treatment with Xtandi 40mg capsule?
Before starting treatment with Xtandi 40mg capsule, your healthcare provider will recommend tests for Prostate-specific antigen (PSA) tests. This blood test measures the level of PSA, a protein produced by the prostate gland that can be elevated in men with prostate cancer. PSA levels can help monitor the progression of the disease and the response to treatment. Other tests also include liver function tests and complete blood count(CBC).
Q 2. What should you do if you missed a dose of Xtandi 40mg capsule?
If you missed taking a dose of Xtandi 40mg capsule, skip this dose. Do not take two capsules to make up for the missed dose. Report to your healthcare provider right away if you missed taking more than two doses of this drug.
Q 3. Who should not take Xtandi 40mg capsule?
Xtandi 40mg capsule is not recommended for people who are allergic to this drug, and its ingredients. Also, women who are pregnant or breastfeeding should avoid taking it, because this drug can harm an unborn baby or pass into breast milk.
Q 4. Can you smoke while on treatment with Xtandi 40mg capsule?
It is not recommended to smoke cigarettes while on treatment with Xtandi 40mg capsule as smoking can reduce the concentration of this drug in the body.
Q 5. How do you know if you have overdosed on Xtandi 40mg capsule?
Watch out for symptoms like fatigue, tiredness, nausea, vomiting, severe headache and seek immediate medical attention from a nearby healthcare facility.
Fact Box of Xtandi 40mg Capsule
Molecule name: Enzalutamide | Therapeutic class: Antineoplastics |
Pharmacological class: Androgen receptor inhibitors | Indications: 1.Advanced prostate cancer |
References
- Astellas Pharma Ltd, [Revised on Oct 2020] [Accessed on 8th Apr 2021], https://www.astellas.us/docs/12a005-enz-wpi.pdf
- Astellas Pharma Europe B.V, Electronic Medicines Compendium (EMC), [Revised on May 2021] [Accessed on 12th Nov 2021], https://www.medicines.org.uk/emc/files/pil.10318.pdf
- Martín LázaroQuintela et al., Enzalutamide: a new prostate cancer targeted therapy against the androgen receptor, Cancer Treatment Reviews. Mar 2015; 41(3): 247-253 [Accessed on 8th Apr 2021],https://ruc.udc.es/dspace/bitstream/handle/2183/21551/Lzro_Enzlutamide.pdf?sequence=3&isAllowed=y
- Marina D. Kaymakcalan and Christy S. Harris, Prostate Cancer, Applied Therapeutics, The Clinical Use Of Drugs, 11th Edition, 2018, 2083-2100.
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