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Yervoi 50mg Injection
Prescription Required
Salt Composition : Ipilimumab
Manufacturer : BRISTOL MYERS SQUIBB
Origin of Medicine : United States of America
1 Vial(s) Of 10ml
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Introduction to Yervoi 50mg Injection
Yervoi 50mg Injection contains active component as Ipilimumab. This medication is used to treat advanced melanoma (a type of skin cancer) that has spread to other parts of the body. It can treat cancer of the lungs, liver, and kidneys in adults. Also used to treat colorectal cancer in adults and children (12 years and older). Cancer is a disorder in which cells multiply uncontrolled and abnormally. Talk to your physician if you have immune system problems (such as ulcerative colitis, Crohn’s disease, lupus, or sarcoidosis), liver problems, a history of inflammation of the lungs, HIV (human immunodeficiency syndrome) infection, or have had an organ transplant before taking Yervoi 50mg Injection.
Like many cancer treatments, Yervoi 50mg Injection can cause side effects, including fatigue, diarrhea, and skin rash, but these side effects are typically manageable with appropriate medical care. The main benefit of Yervoi 50mg Injection is that it can help improve survival in patients with advanced melanoma. Another benefit is it targets the immune system, so it is less toxic to healthy cells than other cancer treatments, such as chemotherapy or radiation therapy.
Uses of Yervoi 50mg Injection
- Advanced melanoma (type of skin cancer)
- Advanced kidney cancer
- Liver cancer
- Colorectal cancer
- Non-small cell lung cancer (type of lung cancer)
Therapeutic Effects of Yervoi 50mg Injection
Yervoi 50mg Injection is a medication that works by helping the body's immune system to attack cancer cells. Specifically, it blocks a protein called CTLA-4, which normally helps regulate immune cells' activity called T cells. By blocking CTLA-4, Yervoi 50mg Injection allows T cells to become more active and better able to recognize and destroy cancer cells. It takes the brakes off the immune system, allowing it to fight cancer better. Doing so can help shrink tumors and improve survival in some patients with advanced melanoma.
Interaction of Yervoi 50mg Injection with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Yervoi 50mg Injection and reduce effectiveness by causing undesirable side effects.
More Information about Yervoi 50mg Injection
- Yervoi 50mg Injection should be stored at room temperature between 20-25°C (68-77°F).
- Keep away from heat, moisture, and light.
- Store in an original package.
- Keep out of reach of children and pets.
How to consume Yervoi 50mg Injection
Yervoi 50mg Injection is typically administered by a healthcare professional through an intravenous (IV) infusion. The medication is prepared as a solution and given for about 90 minutes. The dose will depend on factors such as the patient's weight and overall health and the specific cancer being treated. Treatment is typically given in cycles, with each cycle consisting of several infusions given over weeks or months. If you miss a dose, then it is important to contact your healthcare provider as soon as possible to discuss your options. The timing and frequency of doses can be critical in achieving the maximum benefit from the medication.
Safety Advices for Yervoi 50mg Injection
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Pregnancy
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Yervoi 50mg Injection is not safe for use during pregnancy because it can harm to developing baby.
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Breast Feeding
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It is unknown whether Yervoi 50mg Injection is excreted in milk. So it is better to consult a healthcare provider if you are a breastfeeding mother before taking this medication.
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Lungs
  Yervoi 50mg Injection has been associated with a risk of immune-related adverse events, which can affect the lungs as well as other organs in the body. These events can include pneumonitis (inflammation of the lungs), cough, shortness of breath, and other respiratory symptoms.
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Liver
  Yervoi 50mg Injection has been associated with a risk of immune-related adverse events, including hepatitis (liver inflammation). Patients with preexisting liver disease may be at increased risk of developing liver-related side effects.
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Alcohol
 ÂAlcohol consumption can have negative effects on the immune system and may interfere with the effectiveness of cancer therapies. So it is recommended to avoid taking alcohol while taking Yervoi 50mg Injection.
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Driving
  Patients receiving Yervoi 50mg Injection should be advised to avoid driving or operating machinery if they experience side effects such as fatigue, dizziness, or blurred vision, impairing the patient ability to drive or operate machinery safely.
Side Effects of Yervoi 50mg Injection
Like all medications, Yervoi 50mg Injection can cause side effects, although not everyone who takes it will experience them.Â
Serious:
- Inflammation of the colon (colitis)
- Inflammation of the liver (hepatitis)
- Inflammation of the lungs (pneumonitis)
- Inflammation of the pituitary gland (hypophysitis)
- Inflammation of the skin (dermatitis)
- Nerve damage (neuropathy)
- Hypothyroidism
- Adrenal insufficiency
- Diabetes
Common:
- Fatigue
- Diarrhea
- Itching
- Rash
- Nausea
- Loss of appetite
- Headache
- Insomnia
- Muscle pain
- Joint pain
Word of Advice
Yervoi 50mg Injection is a powerful medication that can have potentially serious side effects. Therefore, following your healthcare provider's instructions for taking the medication and reporting any side effects or changes in your health is important. If you feel any infusion reaction, then immediately contact your doctor. If you are a woman who could become pregnant, use effective birth control during the treatment and for at least three months after the last dose. You need to talk to your physician if you are on a salt-controlled diet this medication contains sodium. It is recommended that patients undergoing cancer treatment eat a diet rich in fruits, vegetables, whole grains, and lean proteins and limit their intake of processed and high-fat foods. Drinking plenty of water and staying hydrated is also important.
FAQs
Q 1. Can I receive vaccinations while on Yervoi 50mg Injection treatment?
It is generally recommended to avoid live vaccines during Yervoi 50mg Injection treatment, as the immune system may be weakened and may not mount an effective response to the vaccine.
Q 2. Can I donate blood while on Yervoi 50mg Injection treatment?
There is no data on the safety of donating blood while on Yervoi 50mg Injection treatment, and it is generally recommended to avoid blood donation during treatment and for at least 5 months after the last dose.
Q 3. Can I develop autoimmune disorders while on Yervoi 50mg Injection treatment?
Yervoi 50mg Injection can cause immune-mediated adverse reactions, including autoimmune disorders. Patients should be monitored for signs and symptoms of autoimmune disorders, such as joint pain, rash, or fatigue, and should inform their healthcare provider immediately if these symptoms develop.
Q 4. Can Yervoi 50mg Injection be used in combination with other cancer treatments?
Yervoi 50mg Injection can be combined with other cancer treatments, such as chemotherapy or radiation therapy. However, the combination may increase the risk of adverse reactions and should only be used under the supervision of a healthcare provider.
Q 5. How long does the effect of Yervoi 50mg Injection last?
The effects of Yervoi 50mg Injection on the immune system can last for several weeks to months after the last dose. However, the duration of the effect may vary depending on the individual and the type of cancer being treated.
Fact Box of Yervoi 50mg Injection
Molecule name: Ipilimumab | Therapeutic class: Anticancer |
Pharmacological class: Monoclonal antibody immunotherapy | Indications: 1. Advanced melanoma (type of skin cancer) 2. Advanced kidney cancer 3. Liver cancer 4. Colorectal cancer 5. Non-small cell lung cancer (type of lung cancer) |
References
- Bristol-Myers Squibb Company, US Food and Drug Administration, [Revised on May 2020] [ Accessed on 15 April 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/125377s110lbl.pdf
- Bristol-Myers Squibb Pharma EEIG, Electronic medicines compendium (emc), [Revised on Jan 2021] [ Accessed on 15th April], https://www.medicines.org.uk/emc/files/pil.4683.pdf
- Matthew D Hellmann et al; Nivolumab plus Yervoi 50mg Injection in Advanced Non-Small-Cell Lung Cancer; The New England Journal of Medicine; Published on Nov 2019; Accessed on 15th April 2023]; https://pubmed.ncbi.nlm.nih.gov/31562796/
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