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Zavedos 5mg Injection
Prescription Required
Salt Composition : Idarubicin
Manufacturer : PFIZER LTD
Origin of Medicine : United States of America
1 Vial(s)
Introduction to Zavedos 5mg Injection
Zavedos 5mg injection contains the active substance Idarubicin hydrochloride. It is an antineoplastic drug that belongs to the class of medications called anthracyclines. It is used in adults and children to treat acute non-lymphoblastic leukemia (ANLL), also referred to as acute myeloid leukemia (AML). It is also used in adults and children as a second-line treatment for relapsed acute lymphoblastic leukemia (ALL). It works by slowing or stopping the growth of cancer cells in your body.Â
Do not take Zavedos 5mg injection if you are allergic to Idarubicin or any other ingredients of this medicine. Inform your physician if you have an infection, liver disease, kidney disease, heart disorder, Stomach problems, and breastfeeding. If your doctor has told you that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.
Zavedos 5mg injection should not be used in pregnant and breastfeeding women. Inform your physician if you are pregnant or breastfeeding. Use effective contraception throughout the therapy to avoid pregnancy. This medicine may affect male fertility. Talk with your doctor if you are planning for pregnancy. The common side effects are diarrhea, nausea, vomiting, stomach cramps, and hair loss.
Uses of Zavedos 5mg Injection
- Acute myeloid leukemia (AML)
- Relapsed acute lymphoblastic leukemia (ALL)
Therapeutic Effects of Zavedos 5mg Injection
Zavedos 5mg injection has antimitotic and cytotoxic effects via a variety of modes of action, it intercalates with DNA to form complexes, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, blocking the relegation component of the ligation-religation reaction catalyzed by topoisomerase II. It interferes with ways in which the cells of your body grow and increase in number and is used in the treatment of cancers.Â
Interaction of Zavedos 5mg Injection with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, vaccinations, nutritional and vitamin supplements, and herbal products. Certain medications may interact with Zavedos 5mg injection and reduce its effectiveness by causing undesirable side effects.
More Information about Zavedos 5mg Injection
- Store under refrigeration 2º to 8ºC
- Protect the medicine from light
- keep the injection away from the reach of children and pets.
- If you have missed any dosing appointments, inform your doctor and schedule immediately.
How to consume Zavedos 5mg Injection
It will be given to you by a doctor or nurse in a hospital or clinic setting trained in cancer chemotherapy. It is given as an intravenous infusion drip (into your vein). Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity, body weight, and other factors.Â
Safety Advices for Zavedos 5mg Injection
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Pregnancy
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Zavedos 5mg injection is unsafe to administer in pregnant women because it may affect the fetus. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant. Using an effective birth control method during the treatment and for 6.5 months after your last dose is necessary. Â
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Breast Feeding
 ÂBreastfeeding is not recommended in patients taking Zavedos 5mg injection because the medicine passes into the breast milk in small amounts and may harm your baby.Â
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Lungs
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It is unknown whether Zavedos 5mg injection can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.
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Liver
  Zavedos 5mg injection should be used with caution in patients with liver disease. Dose adjustments are necessary. Inform your physician if you have any liver problems before initiating the therapy.Â
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Alcohol
 ÂIt is unknown whether consuming alcohol is safe during the treatment with Zavedos 5mg injection. Inform your doctor if you are a chronic drinker.Â
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Driving
  Zavedos 5mg injection may make you feel tired, dizzy, or sleepy. It is unsafe to drive or operate heavy machinery after taking this medicine.Â
Side Effects of Zavedos 5mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.Â
CommonÂ
- Hair loss
- Itchy skin rash
- Diarrhea
- Nausea, vomiting
- Stomach cramps
- HeadacheÂ
SeriousÂ
- Abnormal rhythm
- Chest pain
- Congestive heart failure
- Decreased bone marrow function
- Liver toxicity
- Kidney toxicity
- Infections
Word of Advice
Male patient with a female partner of reproductive potential to use effective contraception during the therapy and for 3.5 months after the last dose. Report symptoms of infection, anemia, or bleeding immediately to your doctor. Do not breastfeed during the treatment and for 14 days after the last dose. This medicine may cause infertility in both men and women, inform your doctor if you are planning for pregnancy before initiating the treatment. This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often. Your doctor may advise you to take certain tests to check for the effectiveness of the therapy.Â
FAQs
Q 1. Can I take vitamin supplements with Zavedos 5mg injection?
Certain medications may interact with the effectiveness of Zavedos 5mg injection including prescription, over-the-counter medicines, vitamin or nutritional supplements, and herbal products. Inform your physician about your medication history.
Q 2. Is Zavedos 5mg injection cardiotoxic?
Heart problems like cardiac arrest, abnormal heart rhythm, and congestive heart failure may occur in patients receiving this medicine for the long term. Inform your physician if you have any pre-existing heart disorders before initiating the treatment.
Q 3. Does Zavedos 5mg injection cause hair loss?
Hair loss is a common side effect of Zavedos 5mg injection. Consult your doctor if you have more hair fall.
Q 4. Is Zavedos 5mg injection an antibiotic?
Zavedos 5mg injection is an anthracycline antibiotic, an anti-cancer drug used to treat certain types of cancer.
Q 5. Is Zavedos 5mg injection a Vesicant?
Vesicants are drugs that can result in tissue necrosis or the formation of blisters (irritation and ulceration of surrounding tissue) when accidentally infused into tissue surrounding a vein. This medicine is classified as a vesicant, hence it will be carefully administered to you by the healthcare professional.
Fact Box of Zavedos 5mg Injection
Molecule name: Idarubicin | Therapeutic class: Antineoplastics |
Pharmacological class: Anthracyclines | Indications: 1. Acute myeloid leukemia (AML) 2. Relapsed acute lymphoblastic leukemia (ALL) |
References
- Zavedos 5mg Powder for Solution for Injection - Summary of Product Characteristics (SmPC) - (emc). www.medicines.org.uk. [revised 2022] [cited 2023 Apr 21]. Available from: https://www.medicines.org.uk/emc/product/5596/smpc
- Idamycin - Idarubicin hydrochloride [cited 2023 Apr 21]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/050734s027lbl.pdf
- Cersosimo RJ. Idarubicin: an anthracycline antineoplastic agent. Clinical Pharmacy. [revised 1992 Feb 1] [cited 2023 Apr 21];11(2):152–67. Available from: https://pubmed.ncbi.nlm.nih.gov/1551297/Â
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