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Zienam 500mg Injection
Prescription Required
Salt Composition : Cilastatin,imipenem
Manufacturer : MSD PHARMACEUTICALS PVT LTD
Origin of Medicine : United States of America
1 Vial(s)
Introduction to Zienam 500mg Injection
Zienam 500mg injection contains an active ingredient called Cilastatin and Imipenem, which belongs to the group of medicines called carbapenem antibiotics. It is used to treat in treating various complex infections in the abdominal region, lung-related infections like pneumonia, and those occurring around the time of childbirth. Additionally, it proves effective against complicated urinary tract infections as well as skin and soft tissue infections. Moreover, this medicine finds utility in managing patients with low white blood cell counts and suspected bacterial-induced fevers. Furthermore, it serves as a viable option for treating bloodstream infections potentially linked to the types of infections.
Do not use Zienam 500mg injection if you are allergic to Cilastatin, Imipenem, Penicillins, Cephalosporins, Carbapenems, or any of its ingredients. Before starting the treatment, you must inform your doctor about any allergies you have, including antibiotic allergies. This is important because severe allergic reactions may require immediate medical attention. Additionally, it's important to let your doctor know if you have colitis, any other gastrointestinal conditions, or kidney or urinary problems, especially if your kidney function is reduced. In cases of reduced kidney function, medicine levels can increase, potentially leading to adverse effects on the central nervous system if dosing is not adjusted appropriately.
Notify your doctor if you have any central nervous system disorders, such as localized tremors or epileptic seizures (fits) and liver conditions. Zienam 500mg injection is not advised for pediatric patients weighing under 30 kg. Additionally, it is not suitable for individuals with meningitis due to the lack of established safety and effectiveness in this context. This medication should not be used for children under one or those with kidney issues. Before starting the treatment, inform your doctor if you are pregnant, planning to get pregnant, or think you may be pregnant or breastfeeding because it is not recommended to use this medicine unless your doctor advises. This medicine contains sodium. Inform your doctor if you are on sodium-free diet.Â
Uses of Zienam 500mg Injection
- Treats bacterial infection
- Serious abdominal infections
- Lung infections (like pneumonia)
- Infections during and after having a baby
- Complicated urinary tract infections
- Complex skin and soft tissue infections
- Used for low white blood cell counts and suspected bacterial infection-related fever
Therapeutic Effects of Zienam 500mg Injection
Cilastatin acts as a blocker of renal dehydropeptidase-I. Because Imipenem, the antibiotic, is broken down by this enzyme found in the kidney, cilastatin is given alongside imipenem to prevent its breakdown and keep it effectiv
Interaction of Zienam 500mg Injection with other drugs
Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications, such as penicillins, cephalosporins, or carbapenems, may interact with Zienam 500mg injection and can cause undesirable side effects.Â
More Information about Zienam 500mg Injection
- Keep out of sight and reach of pets and children.
- Store between 25°C.
- Always check the expiry date before consuming it.
How to consume Zienam 500mg Injection
Zienam 500mg injection will be administered to you by a healthcare professional in a hospital setting. It is usually administered in a vein (intravenous). Your doctor will decide the dose, route of administration, and frequency based on your disease condition and other factors.Â
Safety Advices for Zienam 500mg Injection
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Pregnancy
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The usage of Zienam 500mg injection has not been studied in pregnant women. It should not be used during pregnancy unless your doctor decides the potential benefit justifies the potential risk to the developing baby. Before starting the treatment, inform your doctor if you are pregnant, planning to get pregnant, or think you may be pregnant.Â
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Breast Feeding
 ÂLimited information is available on the use of Zienam 500mg injection during breastfeeding. Your doctor will decide whether you should use this medicine during breastfeeding. So, before starting the treatment, inform your doctor if you are breastfeeding. Contact your doctor for more information.Â
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Lungs
  It is unknown whether Zienam 500mg injection is safe for patients with lung problems. Inform your physician if you have any lung disease before starting the treatment. Contact your doctor if you experience any lung-related symptoms.
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Liver
  Zienam 500mg injection should be used cautiously in patients with liver conditions. Before starting the treatment, inform your physician about pre-existing liver conditions.Â
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Alcohol
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Do not consume alcohol while taking Zienam 500mg injection because your blood pressure may decrease, resulting in dizziness, debility, and fatigue. Please speak with your physician for more information
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Driving
  Do not drive or operate machinery if you experience side effects like dizziness and fatigue from Zienam 500mg injection, as it may affect your ability to do so safely.
Side Effects of Zienam 500mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.
Serious
- Allergic reactions
- Skin peeling
- Stevens Johnsons Syndrome
- Exfoliative dermatitis (severe skin rash with loss of skin and hair)
Common
- Nausea
- Vomiting
- Diarrhea
- Swelling and redness
- Abnormal liver function
- Increased white blood cell count in blood
Word of Advice
Patients with liver conditions should take Zienam 500mg injection cautiously and should inform the doctor about all the underlying medical conditions. Do not stop the medicine until your doctor advises. Notify your doctor if you experience any serious side effects. Your medical professional will inform you if you need any dose adjustments. Contact your doctor for more information.
A positive test known as the Coombs test may arise, indicating the potential presence of antibodies that could harm red blood cells. Your doctor will have a conversation with you regarding this matter. If you have any concerns or questions, don't hesitate to discuss them with your healthcare provider.Â
FAQs
Q 1. Can I use Zienam 500mg injection if I’m pregnant?
Do not consume Zienam 500mg injection during pregnancy unless your doctor advises. Notify your doctor if you are pregnant or planning to get pregnant or think you may be pregnant.
Q 2. Can I use Zienam 500mg injection with other medications?
Before using this medicine, it is essential to consult your doctor, as they can interact with various other medications such as penicillins, cephalosporins, or carbapenems. Getting suggestions from your doctor will help ensure the safe and appropriate use of Zienam 500mg injection with your current medication regimen.
Q 3. What are the side effects of Zienam 500mg injection?
The most common side effects of Zienam 500mg injection are nausea, vomiting, diarrhea, swelling, redness, abnormal liver function, and increased white blood cell count in the blood. If you experience any side effects, talk to your doctor.
Q 4. Is it okay to consume alcohol while taking Zienam 500mg injection?
Do not consume alcohol while taking Zienam 500mg injection because your blood pressure may decrease, resulting in dizziness, debility, and fatigue.
Q 5. How do you manage the side effects of Zienam 500mg injection?
To manage the side effects of Zienam 500mg injection, follow the prescribed dosage and report side effects promptly. Stay hydrated, and monitor blood pressure regularly. Maintain a healthy lifestyle and attend follow-up appointments.
Fact Box of Zienam 500mg Injection
| Molecule Name: Cilastatin + Imipenem | Therapeutic class: Antibiotics |
| Pharmacological class:Â Carbapenem antibiotics | Indications:Â 1. Treats bacterial infection 2. Serious abdominal infections 3. Lung infections (like pneumonia) 4. Infections during and after having a baby 5. Complicated urinary tract infections 6. Complex skin and soft tissue infections 7. Used for low white blood cell counts and suspected bacterial infection-related fever |
References
- Merck Sharp & Dohme Limited, Electronic Medicines Compendium (EMC), [Revised on Jan 2023] [Accessed on 10th August 2023], TIENAM, INN-Imipenem/Cilastatin (medicines.org.uk)
- Merck Sharp & Dohme Limited, US Food & Drug Administration, [Revised on Dec 2016] [Accessed on 10th August 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/050587s074lbl.pdf
- Camille E. Beauduy, Lisa G. Winston, Beta-Lactam & Other Cell Wall- & Membrane-Active Antibiotics, Lange’s Basic & Clinical Pharmacology, 14th Edition, 2018, 795-814.
- KD Tripathi, Beta-Lactam Antibiotics, Essentials of Medical Pharmacology, 8th Edition, 2019, 766-783.
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