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Zosyn 4.5gm Injection
Prescription Required
Salt Composition : Piperacillin,tazobactam
Manufacturer : PFIZER LTD
Origin of Medicine : United States of America
1 Vial(s)
Introduction to Zosyn 4.5gm Injection
Zosyn 4.5gm injection contains two active ingredients called Piperacillin and Tazobactam, which belong to the group of medicines called broad-spectrum penicillin antibiotics and beta-lactamase inhibitors. Piperacillin with Tazobactam is used to kill many types of harmful bacteria in our body. When Piperacillin is given together with Tazobactam, it works more effectively against certain resistant bacteria. This medicine is used to treat bacterial infections in the lower respiratory tract, urinary tract, abdomen, skin, or blood in adults and adolescents.
Zosyn 4.5gm injection also treats bacterial infections in children aged 2-12 years, particularly abdomen infections like appendicitis, peritonitis, and gallbladder infections. Additionally, it is used in patients with low white blood cell counts. It can also be helpful for people with weaker immune systems. In some serious infections, doctors may use it along with other antibiotics to fight the germs effectively. This medicine should not be used in children under the age of 2 years because there is not enough data available to determine its safety and effectiveness in this age group.
Do not use Zosyn 4.5gm injection if you are allergic to Piperacillin, Tazobactam, penicillins, cephalosporins, other beta-lactamase inhibitors, or any of its ingredients. Before taking the medicine, notify your doctor if you have low potassium levels in your blood, liver, or kidney issues and undergoing hemodialysis requires monitoring. Your doctor may conduct regular blood tests during treatment. If you are taking anticoagulants or experience unexpected bleeding, inform your healthcare professional immediately. Notify your healthcare professional if you have convulsions or suspect a new or worsening infection during treatment. Additionally, be aware of haemophagocytic lymphohistiocytosis, a condition involving excessive white blood cell production, and contact your doctor immediately if you experience fever, swollen glands, weakness, lightheadedness, shortness of breath, bruising, or skin rash. Inform your doctor if you are pregnant, planning to get pregnant, or think you may be pregnant or breastfeeding.
Uses of Zosyn 4.5gm Injection
- Treats bacterial infection.
Therapeutic Effects of Zosyn 4.5gm Injection
Piperacillin acts as an antibiotic by stopping the formation of the protective covering in bacteria, which is essential for survival. Tazobactam is a beta-lactamase inhibitor, which helps reduce bacterial resistance and boosts the effectiveness of Piperacillin against bacteria.
Interaction of Zosyn 4.5gm Injection with other drugs
Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications may interact with Zosyn 4.5gm injection and cause undesirable side effects.
More Information about Zosyn 4.5gm Injection
- Keep out of sight and reach of pets and children.
- Do not store above 25°C.
- Protect it from light.
- Do not freeze the medicine.
- Always check the expiry date before consuming it.
How to consume Zosyn 4.5gm Injection
Zosyn 4.5gm injection will be administered to you by a healthcare professional in a hospital setting. Do not self-administer. Your doctor will decide the dose, route of administration, and frequency based on your disease condition and other factors.
Safety Advices for Zosyn 4.5gm Injection
Pregnancy
Zosyn 4.5gm injection is harmful to the unborn baby. Before starting the treatment, inform your doctor if you are pregnant or, planning to get pregnant, or think you may be pregnant. Your doctor will decide if this medicine is right for you.
Breast Feeding
Zosyn 4.5gm injection can pass to a baby in the womb or through breast milk. So, before starting the treatment, inform your doctor if you are breastfeeding. Your doctor will decide if this medicine is right for you.
Lungs
It is unknown whether Zosyn 4.5gm injection is safe for patients with lung problems. Inform your physician if you have any lung disease before starting the treatment. Contact your doctor if you experience any lung-related symptoms.
Liver
Zosyn 4.5gm injection should be used cautiously in patients with liver conditions. Before starting the treatment, inform your physician about pre-existing liver conditions.
Alcohol
It is unknown whether consuming alcohol while taking Zosyn 4.5gm injection is safe. Please speak with your physician.
Driving
Zosyn 4.5gm injection does not alter driving ability. However, if you experience side effects like tiredness or drowsiness, avoid driving and using machines.
Side Effects of Zosyn 4.5gm Injection
Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.
Serious
- Severe anaphylactic reactions
- Stevens-Johnson syndrome
- Toxic epidermal necrosis
- Progressive rashes
- Bleeding
- Anaemia
- Clostridium difficile-associated diarrhea
Common
- Constipation
- Nausea, vomiting
- Headache
- Abnormal kidney test
- Fever
- Insomnia
- Low potassium levels in the blood
- Bronchospasm
Word of Advice
Notify your doctor if you experience diarrhea during or after taking Zosyn 4.5gm injection, notify your healthcare professional immediately, and avoid taking any medication for it without consulting your doctor. Notify your doctor if you have a history of any disease. Notify your doctor if you are allergic to sodium, as this medicine contains sodium. Patients with kidney disorders should use this injection cautiously.
Do not stop the medicine until your doctor advises. Do not breastfeed while taking Zosyn 4.5gm injection unless the doctor advises. Notify your doctor if you experience any serious side effects. Your medical professional will inform you if you need any dose adjustments. Contact your doctor for more information.
FAQs
Q 1. Can I use Zosyn 4.5gm injection if I’m pregnant?
Consult your medical professional regarding the use of Zosyn 4.5gm injection during pregnancy. The potential benefits and risks should be carefully assessed. Your doctor will suggest taking this medicine only if it's necessary.
Q 2. Can I use Zosyn 4.5gm injection with other medications?
Before using Zosyn 4.5gm injection, it is essential to consult your doctor, as they can interact with various other medications. Talking to your doctor will help to ensure the safety and appropriate use of the medicine with your current medication regimen.
Q 3. Is Zosyn 4.5gm injection safe for children below the age of 2 years?
No, Zosyn 4.5gm injection is not recommended for use in children below the age of 2 years due to insufficient data on its safety and effectiveness in this age group.
Q 4. What are the side effects of Zosyn 4.5gm injection?
The common effects of Zosyn 4.5gm injection are constipation, nausea, vomiting, headache, abnormal kidney test, fever, insomnia, low potassium levels in the blood, and bronchospasm. If you experience any side effects, contact your doctor immediately.
Q 5. How to manage the side effects of Zosyn 4.5gm injection?
To manage the side effects of Zosyn 4.5gm injection, follow the prescribed dosage and report side effects promptly. Stay hydrated, and monitor your blood regularly for low potassium levels. Maintain a healthy lifestyle and attend follow-up appointments.
Fact Box of Zosyn 4.5gm Injection
| Molecule Name: Piperacillin + Tazobactam | Therapeutic class: Anti-infectives |
Pharmacological class: 1. Broad-spectrum penicillin antibiotics. 2. Beta-lactamase inhibitors. | Indications: Treats bacterial infection.
|
References
- Wockhardt UK Limited, Electronic Medicines Compendium (EMC), [Revised on March 2023] [Accessed on 31st July 2023], 103276-8.pdf (medicines.org.uk)
- Pfizer, US Food & Drug Administration, [Revised on May 2017] [Accessed on 31st July 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/050684s88s89s90_050750s37s38s39lbl.pdf
- Camille E. Beauduy, Lisa G. Winston, Beta-Lactam & Other Cell Wall- & Membrane-Active Antibiotics, Lange’s Basic & Clinical Pharmacology, 14th Edition, 2018, 795-814.
Disclaimer
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