This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Alfuzosin and solifenacin succinate was approved by US Food and drug administration for the indication to treat Benign prostatic hyperplasia, a condition that causes prostate gland enlargement in men.

Mechanism of Action of undefined

Benign prostatic hyperplasia results in enlarged prostate gland causing urinary obstruction and reduced urine output. Alfuzosin and Solifenacin Succinate function by specifically obstructing postsynaptic alpha receptors in the smooth muscles of the prostate. This action induces muscle relaxation, facilitating urination by easing the passage of urine.

Uses of undefined

Alfuzosin and solifenacin succinate is used to treat benign prostate hyperplasia in men.

undefined Drug administaration and Dosage available

Alfuzosin and solifenacin is available in oral dosage form as tablets containing alfuzosin 10mg and solifenacin 5 mg. It is recommended to be taken after meals. Swallow the medication whole with a glass of water. Don't break, crush, or chew the tablet. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. 

Warnings, Precautions and Side Effects of undefined

Warnings

It is not recommended to take this medication if you are allergic to the active substance Alfuzosin and solifenacin succinate and its components. Do not take more than prescribed since overdose may cause hypoglycemia (low blood sugar). It is advised that you inform your doctor if you are already taking medicines of the same class, such as their alpha-blockers such as Doxazosin, Indoramin, Prazosin, Terazosin, Tamsulosin, or Phenoxybenzamine to avoid serious complications. Also, if you are taking medication to treat high blood pressure, heart disorders, or fungal infections, report it to your doctor immediately. If you have kidney impairment, birth defects of heartbeat or heart failure, and low blood pressure, talk to your doctor before starting your treatment with Alfuzosin + Solifenacin Succinate. Tell your physician about all the medications you have been taking recently before starting treatment.

Precautions

 Before taking Alfuzosin + Solifenacin Succinate, you must notify your doctor about any planned surgical procedures to mitigate the risk of low blood pressure and during your treatment course with this tablet, it is highly unsafe to consume alcohol. Avoid handling machines or driving, as this tablet may cause dizziness and unusual tiredness. It is really important to be safe, so make sure you discuss any concerns you may have with your healthcare professional.

Side Effects

Like any other drug, Alfuzosin and solifenacin succinate also have some side effects. The most common side effects people may experience are Dizziness, painful erection, headache, fatigue, stomach pain, dry mouth, and visual disturbances. Patients may also experience serious side effects like Chest pain , Allergic reaction- rashes, swelling, and trouble breathing. Keep an eye out for these signs and contact your doctor immediately if you experience any of them while receiving therapy.

Word Of Advice

Limit the intake of caffeine and alcohol, as they can irritate the bladder. Try scheduling your bathroom breaks and urinate immediately when you feel the urge.If you notice any unexpected or severe side effects, such as difficulty breathing or an allergic reaction, seek immediate medical attention. Inform your healthcare professional about any other medications or supplements you are consuming to avoid potential drug interactions. If you have any concerns regarding the treatment, consult your healthcare professional for information.

Frequently Asked Question

References

  1. Sanofi, Electronics Medicines Compendium (emc), [ Revised on September 2020] [Accessed on 1st Sept 2023], https://www.medicines.org.uk/emc/files/pil.1475.pdf
  2. Sanofi, U.S FDA, [ Revised on September 2013] [Accessed on 1st Sept 2023],  https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021287s018lbl.pdf
  3. Astellas Pharma Ltd, Electronic medicines compendium (EMC), [Revised on Dec 2022] [ Accessed on 1st Sept 2023], https://www.medicines.org.uk/emc/files/pil.5559.pdf
  4. GlaxoSmithKline, US Food and Drug Administration, [Revised on April 2010] [ Accessed on 1st Sept 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021518s008lbl.pdf
  5. KD Tripathi, Essentials of Medical Pharmacology, Antiadrenergic drugs and drugs for glaucoma, 7th edition, 2013, 142.
  6. KD Tripathi, Essentials of Medical Pharmacology, Anticholinergic drugs and drugs acting on autonomic ganglia, 7th edition, 2013, 119.
  7. Goodman & Gilman's, The Pharmacological Basis of Therapeutics, Muscarinic receptor agonists and antagonists, 12th edition, 2011, 231.

Disclaimer

The drug information on this page is not a substitute for medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.