Uses of undefined

It is used to treat fungal infections of one or more deep body organs. It is also used to treat suspected fungal infections in patients with a raised temperature and neutropenia (reduced number of white blood cells). It is also indicated to treat visceral leishmaniasis, a disease caused by a parasite in certain people.  

undefined Drug administaration and Dosage available

Amphotericin B Injection 

A doctor or nurse in a hospital or clinic setting will give it to you. It is given as an intravenous infusion drip (into your vein). Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity, body weight, and other factors. 

Amphotericin B gel

Always follow your doctor's instructions. Before using the medication, clean and dry the affected region. It is only for external usage. On the affected area, a thin layer of medicine must be applied. It is not necessary to cover treated areas with a plaster or bandage. Hands should be washed before and after application. Avoid using this medication near your eyes, including your eyelids, nose, and mouth.

Warnings, Precautions and Side Effects of undefined

Warnings

Do not receive this injection if you are allergic to Amphotericin B or any of the other ingredients in the medicine. Inform your physician if you have a severe allergic reaction, kidney or liver problems, and if you are having dialysis. Tell your doctor if you have low potassium levels. This injection may cause severe infusion reactions such as flushing, itching, sickness, swelling of the face, mouth, tongue, and airways, and difficulty breathing. Inform your physician immediately if you face any of these symptoms.

Precautions

Before initiating your first treatment, your physician may give you a small amount of Amphotericin B to check for allergic reactions. This medicine contains sugar in each vial; tell your doctor if you have diabetes. Inform your physician if you are pregnant or breastfeeding before initiating the treatment.

Your doctor will decide the dose and quantity of the Amphotericin B gel based on your disease condition. Before applying, the affected region should be clean and dry. You must thoroughly wash your hands before and after using this medication. To avoid reinfection, keep taking this medication even if your symptoms improve.

Side Effects

Common side effects of Amphotericin B injection are skin rash, increased blood sugar levels, decreased potassium levels, diarrhea, nausea, vomiting, anemia, insomnia, shortness of breath, fever, chills, or shivering. Other serious side effects are cardiac arrest, GI bleeding, severe skin reactions, and acute kidney injury. The most common side effects of Amphotericin B gel are skin itching, swelling, redness in the skin, burning, and irritation. 

Word Of Advice

Do not store above (25°C). keep the injection away from the reach of children and pets. This medicine may cause damage to the kidney. Inform your doctor if you have kidney problems. It may be necessary to continue this medication for several weeks to several months to treat certain infections. Stopping the medication too early may result in a return of the infection. Tell your doctor if your condition lasts or gets worse. If you miss a dose of the gel, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Frequently Asked Question

• What is Amphotericin B?
• Amphotericin B is a medication used to treat severe fungal infections, such as invasive or systemic fungal infections. It is a lipid-based formulation of Amphotericin B, designed to enhance drug delivery and minimize side effects.

• What are the possible side effects of Amphotericin B?
• While Amphotericin B is generally well-tolerated, it can still have side effects. Common side effects may include fever, chills, headache, nausea, vomiting, increased blood sugar levels, muscle or joint pain, and infusion-related reactions. In rare cases, it may cause more serious side effects such as cardiac arrest, kidney damage or allergic reactions.

• Can Amphotericin B be used in pediatric patients?
• Amphotericin B can be used in babies more than 1 years old, but the dosage and administration may vary depending on the child's age, weight, and specific medical condition. It is crucial to follow the healthcare provider's instructions and closely monitor the child's response to treatment.

• Why is Amphotericin B less toxic?
• Amphotericin B is less toxic because it is less nephrotoxic. Low toxicity of this medicine may be due to the small number of binding receptors in the drug.

• What are the advantages of using Amphotericin B over other antifungal medications?
• One of the key advantages of Amphotericin B is its lower toxicity compared to conventional Amphotericin B. This makes it a preferred choice, especially for patients more susceptible to antifungal medications' side effects. Additionally, Amphotericin B has a prolonged circulation time in the body, allowing for less frequent dosing.

• Can I discontinue taking Amphotericin B once I feel better?
• Even if you feel better, do not discontinue taking Amphotericin B without consulting your doctor. Before the illness is treated, your symptoms may improve. As a result, it is recommended that you continue your treatment for the suggested term for better and more complete treatment.