Uses of undefined

Baricitinib is primarily indicated for treating moderate to severe rheumatoid arthritis in adults who have not adequately responded to conventional disease-modifying antirheumatic drugs (DMARDs). It is employed to alleviate inflammation and manage autoimmune conditions. Additionally, its potential applications extend to other autoimmune disorders and inflammatory conditions. 

undefined Drug administaration and Dosage available

Baricitinib is typically administered orally, which means it is taken by mouth as tablets. It is available as an oral tablet for easy ingestion. Your healthcare provider will determine the specific dosage and frequency of administration based on your medical condition and individual needs. 

Warnings, Precautions and Side Effects of undefined

Warnings

Baricitinib can increase the risk of serious infections, including tuberculosis, bacterial, fungal, and viral infections. There is a potential increased risk of blood clots, which could lead to deep vein thrombosis or pulmonary embolism. The use of this medication may be associated with an increased risk of certain cancers, including lymphoma. There is a risk of gastrointestinal perforations, particularly in individuals with diverticulitis or gastrointestinal issues. It can impact liver enzymes. It might be associated with mood changes and depression.

Precautions

Screen for TB before starting Baricitinib. Individuals with latent TB should be treated before initiating treatment. Individuals with active infections should avoid using Baricitinib. Individuals at higher risk of blood clots require close monitoring. Regular cancer screenings are recommended. Regular monitoring of liver function is advised. Avoid live vaccines while on Baricitinib due to the potential for reduced vaccine efficacy. Monitor mental health closely.

Side Effects

Common side effects of Baricitinib include upper respiratory tract infections, headaches, increased liver enzymes, elevated blood pressure, alterations in blood cell counts, and increased cholesterol levels. Serious side effects include increased susceptibility to serious infections, blood clot risk, potential for malignancies, gastrointestinal perforations, liver abnormalities, and reactivation of hepatitis B. Additional concerns comprise cardiovascular risks, interstitial lung disease exacerbation, mental health changes, skin cancer risk, potential exacerbation of diabetes, and surgery. 

Word Of Advice

Discuss your cardiovascular health with your healthcare provider before starting Baricitinib. Monitor blood sugar levels closely and consult your healthcare provider if adjustments to diabetes management are needed. Gastrointestinal perforations, liver abnormalities, and possible gastrointestinal issues should be noted. Closely monitor liver enzymes, cholesterol, and blood pressure. Screen for hepatitis B before starting treatment. Vaccination schedules may need adjustment. Stomach and intestinal problems, surgery planning, cataracts, and drug allergies require attention. Use caution in individuals with a history of or risk factors for interstitial lung disease, as it may exacerbate this condition. Consider the risk of lymphoma and other malignancies might be increased with this medication. Protect your skin from sun exposure and report any skin changes to your healthcare provider.  Regular eye check-ups are advisable.

Frequently Asked Question

• What infections should I be concerned about while taking Baricitinib?
• Baricitinib may increase the risk of serious infections. Tuberculosis (TB) should be ruled out before starting treatment.

• Does Baricitinib increase the risk of blood clots?
• Yes, Baricitinib may increase the risk of blood clots, particularly in individuals at higher risk. Close monitoring is recommended.

• When can I expect to see results from Baricitinib?
• The onset of improvement can vary. Some individuals may experience symptom relief within weeks, while others might take longer to respond.

• Should I stop Baricitinib if I feel better?
• No, following your healthcare provider's instructions is important and not discontinuing Baricitinib without consulting them, even if your symptoms improve.

• How do I safely discontinue Baricitinib if needed?
• Stopping Baricitinib should be discussed with your healthcare provider to avoid potential flare-ups of your condition.

• Are mental health changes possible with Baricitinib?
• Yes, mood changes and depression have been reported with Baricitinib. Monitor mental health and seek help if needed.