This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

The combination of Cannabis Leaf Extract, Curcuma Longa Rhizome Extract (commonly known as turmeric), and Hemp Oil has gained increasing attention in recent years for its potential in managing chronic pain, inflammation, and anxiety-related disorders. Clinical trials have shown promising results in using this plant-based blend for therapeutic purposes, particularly in managing chronic pain and inflammation-related conditions like arthritis and neuropathy.

Research dating back to the early 2000s investigated the anti-inflammatory properties of curcumin and cannabinoids, leading to advanced clinical studies in the 2010s. The regulatory approval of this combination in certain countries stems from these studies, emphasising its efficacy and safety in complementary pain management. As of 2023, countries including Canada, the Netherlands, and parts of the U.S. have recognised the medical use of this combination in integrative healthcare settings.

Mechanism of Action of undefined

Cannabis Leaf Extract, Curcuma Longa Rhizome Extract, and Hemp Oil work synergistically to manage pain, inflammation, and anxiety through multiple pathways. Cannabinoids like CBD and THC interact with CB1 and CB2 receptors in the endocannabinoid system, regulating pain, mood, and inflammation. Meanwhile, curcumin from Curcuma Longa inhibits the NF-κB pathway, reducing inflammation and oxidative stress. 

This combination also offers neuroprotective benefits by minimizing oxidative damage and neuroinflammation, making it effective for conditions like neuropathic pain and anxiety. Together, they provide a holistic, natural alternative to synthetic medications with fewer side effects.

Uses of undefined

This combination has been utilised for various therapeutic purposes, including:

  • Chronic Pain Management
  • Inflammatory Disorders
  • Neuropathic Pain
  • Anxiety and Stress Relief
  • Sleep Disorders

undefined Drug administaration and Dosage available

The combination is available in various forms, including:

  • Capsules/Tablets: Typically containing 10-25 mg of cannabinoids and 300-500 mg of curcumin per dose.
  • Oils/Tinctures: Administered sublingually with varying concentrations for personalised dosing.
  • Topical Creams: Applied directly to the skin for localised pain relief.

Dosage depends on the patient’s condition, weight, and severity of symptoms. A healthcare professional should guide its use for optimal results.

Warnings, Precautions and Side Effects of undefined

Warnings

  • Psychoactive Effects: Products containing THC may cause mild euphoria, dizziness, or drowsiness.
  • Drug Interactions: May interact with anticoagulants, NSAIDs, and CNS depressants.
  • Pregnancy and Lactation: Not recommended due to insufficient safety data.

Precautions

  • Driving and Operating Machinery: Avoid these activities if experiencing drowsiness or dizziness.
  • Allergic Reactions: Monitor for signs of allergies, including rashes, itching, or breathing difficulties.
  • Monitoring: Regular liver function tests are recommended due to potential liver enzyme alterations.

Side Effects

Common side effects may include:

  • Drowsiness
  • Dry mouth
  • Mild gastrointestinal upset
  • Lightheadedness
  • Nausea

Severe side effects are rare but may include allergic reactions or liver enzyme elevations.

Word Of Advice

Before using this combination, consult a healthcare professional, especially if you are on existing medications or have underlying health conditions. Adjustments in dosage or monitoring may be necessary to ensure safety and efficacy.

Frequently Asked Question

References

  1. https://pubmed.ncbi.nlm.nih.gov/34775634/
  2. https://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/research-data/compliance-enforcement-report-cannabis-inspection-data-summary/2023-2024.html
  3. https://boheco.com/products/peace-for-mild-chronic-neuropathic-pain-10-capsules-pack-of-1?variant=43999754780885 

Disclaimer

This content is for informational purposes only and does not replace professional medical advice. Always consult a doctor for guidance tailored to your health needs.