This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Diphtheria toxoid and tetanus toxoid are inactivated bacterial toxins used to immunise individuals against diphtheria and tetanus, two life-threatening diseases caused by Corynebacterium diphtheriae and Clostridium tetani. Approved in the mid-20th century, these vaccines are globally recognised for their efficacy in reducing morbidity and mortality rates. 

The World Health Organization (WHO) and regulatory agencies like the FDA recommend their inclusion in routine immunisation schedules. Clinical trials have consistently demonstrated high safety and efficacy profiles, making these vaccines cornerstone interventions in public health initiatives.

Mechanism of Action of undefined

Diphtheria toxoids and tetanus toxoids work by stimulating the immune system to produce antibodies against the diphtheria and tetanus toxins. The toxoids are chemically inactivated toxins that cannot cause disease but mimic the natural toxins to elicit an immune response. Once vaccinated, the body’s immune system “remembers” these toxins and mounts a rapid defence if exposed in the future. This mechanism provides long-term immunity and prevents severe complications associated with these infections.

Uses of undefined

Diphtheria toxoid and tetanus toxoid are FDA-approved for:

  • Prevention of diphtheria and tetanus in children and adults.
  • Booster immunisation to maintain immunity.
  • Part of combination vaccines for broader immunisation, such as DPT and Tdap.

undefined Drug administaration and Dosage available

  • Administration: The vaccine is administered intramuscularly, typically in the deltoid muscle or the anterolateral thigh.
  • Dosages Available: Common dosages include 0.5 mL pre-filled syringes or vials, used according to age and immunisation schedules. Booster doses are recommended every 10 years.

Warnings, Precautions and Side Effects of undefined

Warnings

  • Avoid administration in individuals with a history of severe allergic reactions (e.g., anaphylaxis) to previous doses.
  • Delayed or alternative schedules may be necessary for individuals with acute illnesses or immunosuppression.
  • Interactions with immunosuppressive therapy, such as corticosteroids, may reduce vaccine efficacy.
  • Consult a healthcare provider before administration during pregnancy unless benefits outweigh risks.

Precautions

Administer diphtheria toxoid and tetanus toxoid with caution in individuals with a history of neurological disorders, Guillain-Barré syndrome, or bleeding disorders, as the injection may cause complications. Ensure the patient is seated during administration to avoid fainting-related injuries. In case of incomplete vaccination history, follow catch-up schedules as recommended by health authorities.

Side Effects

Common Side Effects

  • Mild fever.
  • Redness or swelling at the injection site.
  • Fatigue or muscle aches.

Serious Side Effects

  • Severe allergic reactions, such as difficulty breathing or facial swelling.
  • Neurological symptoms like seizures or numbness (rare).
  • Persistent high fever or swelling of the lymph nodes.

Seek immediate medical attention if serious side effects occur.

Word Of Advice

Complete the full vaccination series for maximum protection against diphtheria and tetanus. Inform your healthcare provider of your medical history, including allergies and chronic illnesses. Pregnant women should consult their doctor regarding the safety of these vaccines during pregnancy. Avoid strenuous activities post-vaccination to minimise discomfort. Always adhere to the recommended schedule for booster doses to maintain immunity.

Frequently Asked Question

Disclaimer

This content is for informational purposes only and should not replace professional medical advice. Consult your healthcare provider for personalised guidance.