This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Background and Date of Approval
Dutasteride and Silodosin are used to treat benign prostatic hyperplasia (BPH) in men. Dutasteride and Silodosim belong to the family called 5-Alpha reductase inhibitors and Alpha-1 blockers.
Mechanism of Action of undefined
Dutasteride + Silodosin capsule blocks the conversion of the hormone testosterone to dihydrotestosterone by blocking an enzyme called 5α-reductase in the genital region. This reduces the concentration of dihydrotestosterone in the blood and increases the urine flow rate.
Uses of undefined
Dutasteride + Silodosin treats benign prostatic hyperplasia (BPH) in men with an enlarged prostate. Taking this medication can help to reduce the problems like difficulty in urination, frequent urination, and other related symptoms.
undefined Drug administaration and Dosage available
Take the Dutasteride + Silodosin as your physician advises. Usually, the tablets will be taken with or without food. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking the tablet if your doctor advises you to stop.
Warnings, Precautions and Side Effects of undefined
Warnings
Dutasteride + Silodosin should not be consumed if you are allergic to Dutasteride, Silodosin, or any of its ingredients in the medication. Do not consume this medicine if you have severe liver or kidney problems. Notify your doctor if you have heart disease or if you notice breast lumps or nipple discharge. This medicine is specifically for men and should not be taken by women or children. Pregnant women or those who could become pregnant should not handle the medication if it leaks, as it can harm the baby. If there is any contact, wash the area with soap and water immediately. Do not consume alcohol while taking this medicine.
Precautions
It is advised to use contraceptives to avoid the transfer of semen. Inform your doctor if you are taking this medicine during a PSA test because it can affect PSA blood tests for detecting prostate cancer. Patients should be cautious about driving and operating machinery while taking Dutasteride + Silodosin. Contact your doctor for more information.
Side Effects
The most common side effects of Dutasteride + Silodosin are skin rash, hives, and swelling of the face, eyelids, lips, arms, or legs. Serious side effects while taking Dutasteride + Silodosin are low sperm count and movement, low sex drive, impotence, and enlarged or painful breasts.
Word Of Advice
Before prescribing Dutasteride + Silodosin, your healthcare provider will assess for prostate problems, including cancer. Inform their doctor if you have plans for cataract surgery and about all the underlying medical conditions. Do not stop the medicine until your doctor advises. Do not double-dose the medicine to make up for a forgotten dose. Notify your doctor if you experience any serious side effects. Your medical professional will inform you if you need any dose adjustments. Contact your doctor for more information.
Frequently Asked Question
References
- Kazuhisa Hagiwara et al., Efficacy and Safety of Silodosin and Dutasteride Combination Therapy in Acute Urinary Retention due to Benign Prostatic Hyperplasia: A Single-Arm Prospective Study, BioMed Research International, 2016, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852328/pdf/BMRI2016-4975851.pdf
- J. Goddard, A.N. Turner, Kidney and Urinary Tract Disease, Davidson’s Principles and Practice of Medicine, 22nd Edition, 2014, 461-523.
- Peter J. Snyder, Androgens and the Male Reproductive Tract, Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 13th Edition, 2018, 833-843.
- Rivopharm UK Ltd, Electronic Medicines Compendium (EMC), [Revised on March 2017] [Accessed on 23 June 2023], *Microsoft Word - uk-pl-clean (medicines.org.uk)
- Dailymed, [Accessed on 23 June 2023], DailyMed - SILODOSIN capsule (nih.gov)
Disclaimer
The drug information on this page is not a substitute for medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you are eligible to receive this treatment.
