This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Background and Date of Approval
The U.S. FDA approved macitentan on Oct 18, 2013. It is used to treat long-term treatment of pulmonary arterial hypertension (high blood pressure in the arteries) in adults.
Mechanism of Action of undefined
Macitentan widens the arteries of the lung and makes the arteries pump the blood by the heart, which passes through it. It lowers the blood pressure, relieves the symptoms, and involves the improvising of pulmonary arterial hypertension (PAH).
Uses of undefined
It is used to treat long-term treatment of pulmonary arterial hypertension (high blood pressure in the arteries) in adults. It can be used alone or along with other medicines for PAH.
undefined Drug administaration and Dosage available
Take macitentan tablets are available as 10mg tablets which can be consumed orally. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition.
Warnings, Precautions and Side Effects of undefined
Warnings
Consult your doctor if you are allergic to macitentan or have a liver or lung disorder. Consult your doctor if you are planning to get pregnant or think you may be pregnant or while breastfeeding, and it may cause infertility in males.
Precautions
The safety and effectiveness of the drug have not been established in children , hence it is not recommended in children. Speak with your doctor about your medical history to the doctor before taking this medicine.
Side Effects
The common side effects that are experienced while you are on the treatment with macitentan are anaemia, headache, bronchitis, nasopharyngitis, oedema, pharyngitis, urinary tract infection, hypotension, nasal congestion, and flushing.
Word Of Advice
Your doctor may monitor your liver function and blood level, as this medicine may reduce red blood cells and alter the liver enzyme. Individuals with lactose intolerance or soy allergy should inform their doctor before taking the medicine. Kidney patients should be cautious and inform your doctor before taking medicine, as this may cause a reduction in blood pressure and hemoglobin levels. Inform your doctor, if you are allergic to black pepper (piperine).
Frequently Asked Question
References
- Janssen Pharmaceutica NV., Electronics Medicines Compendium (EMC), [Revised on Jan 2023], [ Accessed on 18 Oct 2023],https://www.medicines.org.uk/emc/files/pil.5223.pdf
- Actelion Pharmaceuticals US, Inc., Food and Drug administration, [Revised on Oct 2018], [Accessed on Oct 18 2023],https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/204410s017lbl.pdf
- KD Tripathi, Essentials of Medical Pharmacology, Androgens and drugs for erectile dysfunction, 7th edition, 2013, 296-300.
Disclaimer
The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details consult your doctor about your medical condition to know if you are eligible to receive this treatment.
