This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Background and Date of Approval
Netupitant, Palonosetron is an antiemetic drug that belongs to the category of medicines known as alkylating agents. It was approved by the FDA in July 2003 to treat Chemotherapy-induced nausea and vomiting.
Mechanism of Action of undefined
It is a type of serotonin receptor antagonist, which works by blocking the action of serotonin in the body that induces nausea and vomiting. The chemotherapeutic trigger zone( CTZ) contains the receptor serotonin, when this CTZ is stimulated, vomiting occurs. Palonosetron prevents the signals from serotonin and helps to reduce the symptoms of nausea and vomiting.
Uses of undefined
Netupitant, Palonosetron is an anti-emetic agent used to treat Postoperative nausea & vomiting. It is also used to treat Chemotherapy induced nausea & vomiting.
undefined Drug administaration and Dosage available
Netupitant,Palonosetron is a prescription drug available in tablet and injection form. The medicine will be administered to you by a healthcare professional in a hospital setting. This injection will be given intravenously into a vein in your arm or hand. Do not self-administer this medicine. The dose of the injection will be decided by your doctor based on your disease condition and other factors. Palonosetron Hydrochloride Injection is usually given about 30 minutes before you receive your anti-cancer medicine (chemotherapy) or right before anaesthesia for surgery. If you are taking palonosetron as an oral tablet, it should be swallowed whole with a glass of water, with or without food, as directed by your healthcare provider.
Warnings, Precautions and Side Effects of undefined
Warnings
Netupitant, Palonosetron is not recommended in patients who have hypersensitivity reactions. This medicine may cause allergic reactions in some people. Symptoms of an allergic reaction include hives, difficulty breathing, swelling of the face or throat, and a rapid heartbeat. If you experience any of these symptoms, consult your doctor immediately.
Precautions
Netupitant, Palonosetron may cause QT prolongation, which is a condition that can cause an irregular heartbeat. This is more likely to occur in people who have a history of heart problems. If you have a history of heart problems, tell your doctor right away. Inform your physician if you have any liver related disease, lung disease, blood/bleeding problems, or infection and about all the other prescribed, over-the-counter medicines, vitamins, nutritional supplements, or herbal medications you take. It is not known whether palonosetron is safe for use during pregnancy or while breastfeeding. If you are pregnant or breastfeeding, be sure to talk to your doctor before taking palonosetron. This medicine may cause drowsiness or dizziness. It is unsafe to drive vehicles or operate heavy machinery after taking Palonosetron Injection because Palonosetron contains a small amount of alcohol which may cause dizziness and impair your concentration.
Side Effects
The common side effects of Netupitant, Palonosetron are headache, fatigue, dizziness, abdominal pain. Other serious side effects include hives, swollen face, breathing trouble, and chest pain. Inform your physician if you face any of the symptoms.
Word Of Advice
Talk to your physician if you have a history of repeated constipation, blockage in the bowel, heart problems, or imbalance of certain minerals (such as potassium and magnesium) in your blood before taking Netupitant, Palonosetron. Inform your doctor or nurse if you are taking any medicines that affect your heartbeat because they could cause a heartbeat problem when taken with Palonosetron solution for injection. Store Netupitant, Palonosetron in the original package at room temperature (25°C). Do not freeze. Keep it out of reach from children and pets. It is important to get the dose at the scheduled time. If you missed the schedule, contact your doctor and reschedule the dose.
Frequently Asked Question
References
- Accord Healthcare SLU, Electronic medicines compendium (emc), [Revised on Feb 2021] [ Accessed on 01st March 2023], https://www.medicines.org.uk/emc/files/pil.7235.pdf
- Fresenius kabi, US Food and Drug Administration, [Revised on Dec 2018] [Accessed on 01st March 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/208109s001lbl.pdf
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Treatment of disorders of bowel motility and water flux, 12th edition, 2011, 1341.
- KD Tripathi, Essentials of Medical Pharmacology, Antiemetic, prokinetic and digestant drugs, 7th edition, 2013, 669.
Disclaimer
The drug information on this page is not a substitute for medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.
