Uses of undefined

Nintedanib is used to treat idiopathic pulmonary fibrosis (IPF), a chronic fibrosing lung disease with a progressive phenotype, systemic sclerosis. This interferes with the production and migration of fibroblasts responsible for lung scars and affects its signaling. This helps to reduce further scarring and stiffening of the lungs.

undefined Drug administaration and Dosage available

Take Nintedanib as advised by your physician. Swallow the medicine with a glass of water. Do not crush, chew, or open the medicine. Your doctor will decide the correct dose and duration based on your age, body weight, and disease condition. Do not stop taking Nintedanib unless your doctor advises you to stop.

Warnings, Precautions and Side Effects of undefined

Warnings

Notify your doctor if you have a history of bleeding or blood clots (arterial thromboembolic). Nintedanib may cause liver function impairment (hepatic impairment) and embryo-fetal toxicity. Hence notify your doctor before starting the treatment. This medicine should not be used if you have severe liver or heart disorders. This medicine may cause gastrointestinal perforation and elevation in liver enzymes. It is not advised to get pregnant while under this treatment. Discuss the effect of contraception because birth pills may not work properly in women. Consult your doctor for more information. Certain medications include a P-glycoprotein (P-gp), CYP3A4 inhibitor, Ketoconazole, Anticoagulants, St. John’s wort, Laxatives, and other drugs, interacting with Nintedanib may reduce effectiveness by causing undesirable side effects. Inform your doctor if you take other medicines. 

Precautions

Before starting the treatment, your doctor may conduct a liver function test at the regular interval of the first three months. Abnormalities, such as dark or brown urine, bruises, bleeding than usual, or jaundice, must be notified immediately to your doctor. Nintedanib capsules may cause harm to the unborn baby. Tell your doctor if you are pregnant or planning to get pregnant before taking this medicine. Continue to use the contraception for three months, even after receiving the final dose. Breastfeeding is not recommended while taking Nintedanib. Because the medicine can pass into breast milk, potentially harming a nursing infant. Consult the doctor for more information. Inform your physician if you experience allergic reactions to Nintedanib.

Side Effects

The most common side effects of Nintedanib are nausea, vomiting, diarrhea, fever, skin ulcer,  gastrointestinal perforation, altered liver function, decreased appetite, headache, weight loss, and hypertension.

Some serious effects are likely to occur while you are on the treatment with Nintedanib are bronchitis, myocardial infarction, bleeding problems, pneumonia, increased protein in the urine (proteinuria), major bleeding yellow eyes, dark urine, pain at the upper right side of the stomach, severe stomach cramps, bloating, fever and chills chest pressure or pain at the left side of the body.

Word Of Advice

Before starting the treatment, it is recommended to perform a liver function test. Store at room temperature of 20°C to 25°C. Protect from light and moisture. Keep out of reach and sight of children and pets. It is unknown whether consuming alcohol while taking a Nintedanib capsule is safe. Please speak with your physician. Avoid smoking while taking Nintedanib because it may reduce the effectiveness of the medicine. Inform your physician if you have bleeding problems, hypertension, heart problems, or weak blood vessels. 

Frequently Asked Question

• How does Nintedanib work in the body? 
• Nintedanib works by inhibiting several signaling pathways that are involved in the formation of scar tissue in the lungs. It targets the activity of certain enzymes and growth factors that promote the growth of fibroblasts, which are the cells responsible for producing collagen and other proteins that form scar tissue in the lungs.

• Can Nintedanib cure idiopathic pulmonary fibrosis (IPF)? 
• Nintedanib is not a cure for idiopathic pulmonary fibrosis (IPF). It is a medication that can help slow the progression of the disease by reducing the formation of scar tissue in the lungs. It is important to continue taking nintedanib as prescribed by your doctor, even if you start feeling better. 

• How can I manage diarrhea while taking Nintedanib? 
• If you experience diarrhea while taking Nintedanib, it is important to stay hydrated by drinking plenty of fluids. Your doctor may also recommend over-the-counter medications or prescription medications to help manage your diarrhea. If your diarrhea is severe or persistent, you should contact your doctor.

• Can Nintedanib cause liver damage? 
• Nintedanib may cause liver function abnormalities, which may indicate liver damage. It is important to have regular blood tests to monitor your liver function while taking nintedanib. If you experience symptoms of liver damage, such as jaundice or abdominal pain, you should contact your doctor immediately.

• What dosage of Nintedanib should I take? 
• Your doctor will decide the correct dose and duration for you based upon your age, body weight and disease condition. Do not stop taking Nintedanib unless your doctor advises you to stop. As with all medications, it is important to follow the dosage instructions provided by your healthcare provider and to consult them for any questions or concerns.

• Why is liver enzyme getting elevated during treatment with Nintedanib? 
• The reason for this elevation is not completely understood, but it is thought to be related to the drug's effects on certain enzymes involved in liver function. The elevation in liver enzymes is generally mild and temporary, and typically resolves on its own or with dose adjustment of the Nintedanib capsules.