Uses of undefined

Paclitaxel has been developed to treat certain forms of breast cancer, ovarian cancer, non-small cell lung cancer and AIDS-induced Kaposis sarcoma in patients who have not responded well to previous anticancer therapies.

undefined Drug administaration and Dosage available

Paclitaxel is available in the form of injection in the doses 30mg, 100mg, 260mg and 300mg. Your healthcare provider will calculate the ideal dose according to your condition and administer it as an intravenous infusion after dilution.

Warnings, Precautions and Side Effects of undefined

Warnings

• Sensory neuropathy: It may occur frequently and could require dose reduction or treatment interruption.
• Sepsis: It can occur in patients receiving Paclitaxel in combination with gemcitabine, with or without neutropenia. Treatment should be interrupted until sepsis resolves and neutrophils are at least 1500 cells/mm³, then resume treatment at reduced dose levels.
• Pneumonitis: It occurs with the use of Paclitaxel in combination with gemcitabine; permanently discontinue treatment with both drugs.
• Hepatic impairment: It can increase exposure and toxicity of paclitaxel. Consider dose reduction and closely monitor patients with hepatic impairment.
• Fetal harm: Advise patients of the potential risk to a fetus and recommend effective contraception, as Paclitaxel can cause fetal harm.
• Contraindications: Do not take Paclitaxel Injection if allergic to paclitaxel, polyoxyethylated castor oil, or any of its ingredients.
• Monitoring: Periodic monitoring of complete blood counts, blood sugar, electrolytes, liver panel, and kidney parameters is advised to prevent serious complications.
• Inform your doctor: If you have a history of stomach ulcers, anaemia, lung disease, heart, liver, skin, or kidney problems.
• Pre-surgery precautions: Inform your physician before undergoing surgery or dental procedures.

Precautions

 It is not known if Paclitaxel causes harm to an unborn baby. Tell your healthcare provider before beginning this treatment if you are pregnant or planning to have a baby. It is advised for both men and women to follow proper contraceptive methods during and for 3 months after the last dose of Paclitaxel. Avoid breastfeeding your baby while you are on the treatment and for 2 weeks after the last dose of Paclitaxel.

Side Effects

Side effects are unwanted symptoms caused by medicines. Although all drugs can cause side effects, not everyone experiences them.

Common side effects of Paclitaxel include:

• Diarrhea
• Nausea
• Vomiting
• Hair loss
• Rashes
• Decreased blood counts
• Joint pain
• Muscle pain
• Infections
• Changes in liver function tests
• Abnormal heartbeat
• Decreased appetite
• Swelling of hands and feet
• Dehydration
• Numbness and tingling sensation

Serious side effects of Paclitaxel include:

• Allergic reactions
• Fever
• Breathing trouble
• Other unusual reactions (immediate medical attention required)

Word Of Advice

Ensure that you stay hydrated and maintain a balanced diet. Avoid driving or operating heavy machines if you experience dizziness or tiredness while on treatment with Paclitaxel. 

Frequently Asked Question

• Is Paclitaxel prescribed as a monotherapy?
• Paclitaxel is prescribed as a monotherapy and also as a maintenance therapy for treating non-small cell lung cancer, breast cancer, ovarian cancer and Kaposis sarcoma.

• What tests are essential before starting treatment with Paclitaxel?
• Before starting treatment with Paclitaxel, your healthcare provider will recommend complete blood count, liver function tests, kidney function tests and signs of dehydration.

• Is it safe to consume alcohol during treatment with Paclitaxel?
• Consumption of alcohol is not recommended while on treatment with Paclitaxel. Discuss with your healthcare provider before starting treatment with Paclitaxel if you drink alcohol on a regular basis.

• How long does it take to recover from Paclitaxel?
• It typically takes few days to a week after receiving Paclitaxel Injection for muscle and joint pain to subside. You may need to take painkiller medications on advice of your doctor if your pain is severe.

• Who should not receive Paclitaxel Injection?
• People with very low WBC count (less than 1500 cells/mm3) and those allergic to Paclitaxel, polyoxyethylated castor oil and other excipients of the medicine should not receive Paclitaxel Injection.

• Can you smoke while on treatment with Paclitaxel?
• It is not recommended to smoke cigarettes while on treatment with Paclitaxel as smoking can reduce the concentration of Paclitaxel in the body.

• How should you store Paclitaxel?
• Store Paclitaxel Injection at 20-25°C, away from the reach of children.