This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Palmitoylethanolamide (PEA), Boswellia, and Pine Bark Extract have gained attention for their synergistic effects in managing inflammation and chronic pain. PEA, a naturally occurring fatty acid amide, was first identified in the 1950s. Clinical studies have shown its effectiveness in modulating inflammation and neuropathic pain. At the same time, Boswellia, derived from the resin of Boswellia serrata, has been used in traditional medicine for centuries for its anti-inflammatory properties. Pine Bark Extract, rich in polyphenols and proanthocyanidins, has been studied extensively for its antioxidant and vascular benefits.

Although these compounds are classified as nutraceuticals or dietary supplements in many countries, regulatory approval dates vary by region. For example, PEA has been utilised as a dietary supplement since the early 2000s and is often included in combination therapies for pain relief. Boswellia and Pine Bark Extract have a long history of use in herbal medicine, with modern clinical trials highlighting their efficacy in joint and cardiovascular health.

Mechanism of Action of undefined

The combined action of PEA, Boswellia, and Pine Bark Extract targets inflammation and oxidative stress through distinct yet complementary pathways:

  • PEA: Acts on the endocannabinoid system by binding to peroxisome proliferator-activated receptors (PPAR-α), reducing pro-inflammatory cytokine production and neuroinflammation.
  • Boswellia: Inhibits 5-lipoxygenase (5-LOX), an enzyme responsible for leukotriene synthesis, thereby reducing inflammation at the cellular level.
  • Pine Bark Extract: Neutralizes free radicals and enhances endothelial function through its potent antioxidant properties, supporting vascular health and reducing oxidative damage.

Uses of undefined

This combination is widely used in:

  • Neuropathic pain management (e.g., sciatica, carpal tunnel syndrome).
  • Joint health, including osteoarthritis and rheumatoid arthritis.
  • Inflammatory conditions such as asthma and inflammatory bowel disease.
  • Cardiovascular support through improved circulation and reduced oxidative stress.

undefined Drug administaration and Dosage available

The formulation is typically available in combination capsules or tablets. Depending on the severity of the condition and patient response, 600–1200 mg/day of the combined formula is divided into 2-3 doses.

A healthcare provider may adjust the dosage for specific conditions, such as chronic pain or inflammatory disorders. Always adhere to the dosage instructions on the product label or consult a medical professional.

Warnings, Precautions and Side Effects of undefined

Warnings

  • It is not suitable for individuals with hypersensitivity to any of the ingredients.
  • It may interact with anticoagulants or anti-inflammatory medications.
  • Avoid use during pregnancy or breastfeeding unless directed by a healthcare provider.

Precautions

  • Consult a doctor before use, especially for individuals with chronic illnesses such as liver or kidney disease.
  • Discontinue use if allergic reactions or gastrointestinal discomfort occur.
  • Monitor for potential drug interactions if taking other medications.

Side Effects

Generally well-tolerated when taken at recommended dosages. Potential side effects include:

  • Mild gastrointestinal upset (e.g., nausea, bloating).
  • Allergic reactions (rare).
  • Headache or dizziness in sensitive individuals.

Word Of Advice

This combination represents a promising approach for managing inflammation and chronic pain without the risks linked with long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs). Always purchase from reputable brands and verify the quality of the ingredients. For optimal results, consult a expert to determine the appropriate dosage and ensure compatibility with existing therapies.

Frequently Asked Question

References

  1. Tafuri A, Panunzio A, De Mitri R, Benetti F, Gaio E, Pagliarulo V. Micronized Palmitoylethanolamide, Hempseed Oil, and Maritime Pine Bark Dry Extract (Pelvipea®) for Pelvic Pain: An In Vitro Study for Urothelial Inflammation Treatment. Cells. 2023 Feb 14;12(4)https://pmc.ncbi.nlm.nih.gov/articles/PMC9953806/
  2. https://www.webmd.com/vitamins/ai/ingredientmono-1596/palmitoylethanolamide-pea
  3. https://leohb.com/combination-ingredients/boswellia-p-e-a/ 

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice. Always consult a doctor before starting new supplements or treatments.