Uses of undefined

Pazopanib has been developed to treat a type of kidney cancer (Renal cell carcinoma) and soft tissue cancer after disease progression and inadequate response to other anticancer therapies.

undefined Drug administaration and Dosage available

Pazopanib is available in the form of tablets in the doses 200mg and 400mg. The usual recommended dose is 800mg once a day without food. You can take this medicine an hour before food or two hours after your meals. For patients with moderate liver impairment, the usual recommended dose is 200mg once daily. Your healthcare provider will adjust the dosing according to how well your body tolerates this medication.

Warnings, Precautions and Side Effects of undefined

Warnings

Contact your doctor immediately if you experience abnormal heart rhythm, seizure, muscle cramps, fever, infection, or severe bleeding. During the Pazopanib treatment, your doctor may periodically monitor your complete blood counts, blood pressure, ECG, blood sugar, electrolytes, thyroid panel, urine test (for proteinuria) liver and kidney parameters to check for the presence of liver toxicity, heart problems, kidney impairment, bleeding, blood clots, pneumonitis, tumor lysis syndrome, and infections and also to prevent serious complications. Report to your doctor if you have been diagnosed with diabetes, hypertension, problems in your heart, liver, skin, kidneys or blood disorders. It is not recommended to undergo surgical procedures while on treatment with Pazopanib Tablet due to the high risk of bleeding. Discuss with your healthcare provider and stop taking Pazopanib Tablet one week before and two weeks after undergoing surgical and dental procedures. Get immediate medical attention if you experience severe headaches, vision changes, confusion or dizziness.

Precautions

Pazopanib significantly impairs fertility and may also cause harm to an unborn baby. Tell your healthcare provider before beginning this treatment if you are pregnant or planning to have a baby. It is advisable for both men and women to follow proper contraceptive methods during and two weeks after the last dose of Pazopanib. Avoid breastfeeding your baby while you are on the treatment and two weeks after the last dose as Pazopanib can impact the growth and development of the baby by passing into the breast milk.

Side Effects

The common side effects that are likely to occur while you are on the treatment with Pazopanib are high blood pressure, diarrhoea, nausea, hair colour changes, loss of appetite, vomiting, tiredness, weight loss, musculoskeletal pain, headache, breathlessness and skin discolouration. If you experience severe headache, chest pain, blood in cough, weakness on one side of the body, trouble speaking, or confusion, report to your doctor immediately.

Word Of Advice

Pazopanib can make you feel dizzy and weak. Avoid driving or operating heavy machines if you experience dizziness, confusion, or tiredness while on treatment with Pazopanib. 

Frequently Asked Question

• Is Pazopanib chemotherapy medicine?
• Pazopanib is not a chemotherapy medication, but it comes under targeted therapy for cancer as it acts specifically against cancer cells.

• Should male patients use contraception while on treatment with Pazopanib Tablet?
• Male patients with female sexual partners should use an effective barrier contraceptive (condoms) during and two weeks after the last dose even if they have already undergone vasectomy.

• Is it safe to undergo a surgery during the treatment with Pazopanib?
• Pazopanib is associated with increased risk of bleeding complications and poor wound healing. Hence it is suggested to avoid planning for surgery and tell your physician before you undergo surgery or dental procedures. Your healthcare provider will suggest stopping the medication a week prior to surgical procedure.

• What should you do if you overdose on Pazopanib Tablet?
• If you take an additional dose of Pazopanib Tablet, report to your healthcare provider right away and go to the emergency department of a hospital.

• What should you not take with Pazopanib?
• It is not recommended to take grapefruit and grapefruit juice while on treatment with Pazopanib. Tell your healthcare provider if you are taking any prescription medicines, over the counter drugs, vitamins or herbal supplements.

• When should you notify your physician?
• Get in touch with your healthcare provider immediately if you experience abnormal heart rhythm, seizure, muscle cramps, fever, infection or severe bleeding.

• How should you store Pazopanib?
• Store Pazopanib tablets at room temperature, away from the reach of children.