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Apigat 2.5mg Tablet
Prescription Required
Salt Composition : Apixaban
Manufacturer : NATCO PHARMA LTD
Origin of Medicine : India
30 Tablet(s) In A Bottle
Introduction to Apigat 2.5mg Tablet
Apigat 2.5mg tablet is a direct oral anticoagulant (DOACs) drug belonging to the category of medicines known as Factor Xa Inhibitors, containing the active ingredient Apixaban. It is used for the prophylaxis of deep vein thrombosis (blood clots in the veins of your legs), which may lead to pulmonary embolism (clots occurring in the blood vessels of your lungs), in patients who have undergone hip or knee replacement surgery. This drug also reduces the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation(AF).
Some formulations of this drug may contain lactose as an inactive ingredient in which the body is unable to digest lactose, a sugar found in milk and dairy products. It can cause symptoms such as bloating, and abdominal pain. If you have lactose intolerance, inform your doctor before starting this therapy. This drug is contraindicated in patients with hepatic disease associated with coagulopathy and clinically relevant bleeding risk, and it is not recommended in patients with severe hepatic impairment. It is essential to inform your doctor if you have a history of any bleeding disorders, liver or kidney disease, or if you're taking any other medications, including over-the-counter drugs, supplements, or herbal remedies. This medicine can interact with other anticoagulant medications and it increases the risk of spinal or epidural hematoma (a blood clot that forms in the spinal canal), particularly if patients undergo spinal procedures or receive spinal anesthesia. Therefore, patients taking this drug should inform their doctor before undergoing any medical procedures, including dental work or surgery, so that appropriate precautions can be taken. Clinicians should also monitor patients frequently for signs and symptoms of neurological impairment, such as numbness or tingling in the arms or legs, weakness, or loss of bowel or bladder control. If these symptoms occur, urgent treatment is necessary to prevent further neurological damage.
Consult your doctor before using this medication if you are pregnant or plan to have a baby. This medicine is not recommended for pregnant women as it may cause fetal harm. Your healthcare practitioner will conduct a pregnancy test before you start treatment with this tablet. Discuss with your doctor about the effective birth control methods and utilize them for at least two weeks following the last dose.
Uses of Apigat 2.5mg Tablet
- Prophylaxis of Deep vein thrombosis(DVT)
- Prevent blood clots
Therapeutic Effects of Apigat 2.5mg Tablet
It is a direct oral anticoagulant (DOAC) that works by inhibiting the activity of factor Xa, which is a protein involved in the blood clotting process. Specifically, this drug binds to the active site of factor Xa and blocks its ability to convert prothrombin to thrombin. Thus, preventing the formation of blood clots.
Interaction of Apigat 2.5mg Tablet with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Apigat 2.5mg tablet and reduce effectiveness by causing undesirable side effects.
More Information about Apigat 2.5mg Tablet
- Store Apigat 2.5mg tablet at a controlled room temperature(20°C to 25°C).
- Keep it out of reach from children.
How to consume Apigat 2.5mg Tablet
Your doctor will decide the dose and duration of Apigat 2.5mg tablet based on the disease condition. Always take this medicine as prescribed by your doctor. The recommended starting oral dose of apixaban is 2.5 mg twice daily. Take the tablet at the same time every day, with or without food. Do not chew, crush, or break the tablet. Swallow the whole tablet with water. If you forgot to take the tablet, simply take your next dose at the scheduled time. Do not take a double dose to make up for a forgotten dose.
Safety Advices for Apigat 2.5mg Tablet
Pregnancy
Apigat 2.5mg tablet is not recommended for pregnant women as it may cause fetal harm. Consult your doctor if you are pregnant or planning for pregnancy during the treatment.
Breast Feeding
It is not known if Apigat 2.5mg tablet passes into your breast milk or if it will affect your baby. Please consult your doctor before breastfeeding.
Lungs
Inform your doctor if you have any lung problems before taking Apigat 2.5mg tablet.
Liver
It is unsafe to use Apigat 2.5mg tablet in severe liver failure patients. Dose adjustments are required in severe hepatic impairment. Consult your physician if you have any liver diseases.
Alcohol
It is unknown whether consuming alcohol while taking Apigat 2.5mg tablet is safe. Please speak with your physician.
Driving
It is safe to travel, drive vehicles or operate heavy machinery after taking the Apigat 2.5mg tablet. This medicine does not impair your ability to drive or use machines.
Side Effects of Apigat 2.5mg Tablet
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious
- Allergic reactions
- Abnormal liver function
- Low blood pressure, fainting
- Bleeding in vagina, stomach, nose, red stools.
- Allergic reactions like swelling in lips, face, throat.
- Bleeding in brain
Common
- Skin rash
- Hair loss
- Itching
- Reduced number of platelets
Word of Advice
Apigat 2.5mg tablet increases the chances of bruising, so it is important to be careful when using sharp objects or participating in activities that may result in injury. It is necessary to inform your doctor before undergoing any medical procedures, including dental work or surgery, so that precautions can be taken. Let your doctor know about any other medications you are taking, including over-the-counter drugs, supplements, or herbal remedies. Maintain a consistent intake of foods that are high in fiber, such as fruits, vegetables, and whole grains, this can help to regulate bowel movements and reduce the possibility of constipation, which can increase the risk of bleeding.
FAQs
Q 1. What is the purpose of the Apigat 2.5mg tablet?
Apigat 2.5mg tablet is commonly used to prevent strokes and blood clots in people with atrial fibrillation, deep vein thrombosis, or pulmonary embolism.
Q 2. What foods to avoid when taking Apigat 2.5mg tablet?
There are no specific foods that need to be avoided while taking Apigat 2.5mg tablet.
Q 3. What should I avoid while taking Apigat 2.5mg tablet?
It is advised to avoid activities that may increase the risk of bleeding, such as contact sports, heavy lifting, or prolonged sitting or standing. Be careful when using sharp objects such as razors and knives.
Q 4. What is the most common risk of Apigat 2.5mg tablet therapy?
The risk of bleeding with Apigat 2.5mg tablet therapy is influenced by several factors, including age, weight, kidney function, and the presence of other medical conditions.
Q 5. How does the Apigat 2.5mg tablet work?
It is a direct oral anticoagulant (DOAC) that works by inhibiting the activity of factor Xa, which is a protein involved in the blood clotting process. Specifically, this drug binds to the active site of factor Xa and blocks its ability to convert prothrombin to thrombin. This, in turn, prevents the formation of blood clots.
Q 6. Is there any special diet that I should follow while taking Apigat 2.5mg tablet?
Unless your doctor advises you to avoid certain foods, follow a healthy diet. Please consult your doctor for more advice on food and diet.
Fact Box of Apigat 2.5mg Tablet
Molecule name: Apixaban | Therapeutic class: Anticoagulants |
Pharmacological class: Oral Factor Xa Inhibitors | Indications: 1. Prophylaxis of Deep vein thrombosis(DVT) 2. Prevent blood clots |
References
- Bristol Myers Squibb/Pfizer EEIG; Electronic Medicines Compendium; [Revised:2021] [Accessed on 03/Apr/2023] https://www.medicines.org.uk/emc/files/pil.4756.pdf
- Highlights of prescribing information; food and drug administration. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/211964s000lbl.pdf [Accessed on 03/Apr/2023].
- Annex I summary of Product Characteristics - European Medicines Agency; Available at: https://www.ema.europa.eu/en/documents/product-information/eliquis-epar-product-information_en.pdf [Accessed on 03/Apr/2023].
- Katherine Victoria Hurst, John Matthew O’Callaghan and Ashok Handa; Quick reference guide to Apixaban; Published 2017 [Accessed on 03/Apr/2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513886/#__ffn_sectitle
- SL Greig; Apixaban: A review in venous thromboembolism; [Published:2016] [Accessed on 03/Apr/2023] https://pubmed.ncbi.nlm.nih.gov/27653758/
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Modulation of Cardiovascular Function, 12th edition, 2011, 867.
- Bertram.G.Katzung, Basic and Clinical Pharmacology, Drugs Used to Treat Diseases of the Blood, Inflammation, & Gout, 14th edition, 617.
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