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Bucelon 60mg Injection
Prescription Required
Salt Composition : Busulfan
Manufacturer : CELON LABORATORIES LTD
Origin of Medicine : India
1 Vial(s) Of 10ml
Introduction to Bucelon 60mg Injection
Bucelon 60mg injection is an anti-cancer (antineoplastic/cytotoxic) chemotherapy drug. It is an alkyl sulfonate belonging to the class alkylating agent. It is indicated for treating blood cancers, such as chronic myelogenous leukemia (A type of cancer that causes an increase in white blood cells). It is given as a treatment to prepare the bone marrow to receive healthy blood-forming cells (stem cells) from a donor to replace their stem cells that have been destroyed by treatment with radiation or high doses of chemotherapy).Â
Chronic myelogenous leukemia is an uncommon type of cancer that affects bone marrow (soft, spongy tissue that produces blood cells for your body). It causes an increase in white blood cell count. Common side effects of Bucelon 60 mg injections are decreased white blood cells count, dizziness, shortness of breath, mouth inflammation, nausea, diarrhea, difficulty sleeping, skin rashes, and fever. Drink plenty of fluids while you are taking this medicine.  Â
Bucelon 60 mg injection can cause a severe decrease in bone marrow activity. If you are taking any other prescribed or non-prescribed medications that decrease the blood cell count, talk to your healthcare professional before taking the medications. It affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, cough, mouth sores, or unusual bleeding or bruising.
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Uses of Bucelon 60mg Injection
- Hematopoietic progenitor cell transplantation
- Chronic myelogenous leukemia
- Polycythaemia vera (a type of cancer that causes an increase in red blood cells)
- Thrombocythemia (increased number of platelets in the blood)
- Myelofibrosis (type of blood cancer where scar tissues are formed in bone marrow)
- Hemoglobinopathies (a genetic disorder that produces abnormal hemoglobin)
- Brain Malignancies
Therapeutic Effects of Bucelon 60mg Injection
Bucelon 60 mg injection works by interfering with the DNA replication process, which is necessary for the cells to divide. It stops tumor growth by inhibiting cell division. It causes cytotoxicity by reversibly binding to nucleophilic groups on different cell components. Alkylation of DNA is most likely the crucial cytotoxic reaction that kills tumor cells. It damages the DNA and RNA of the cancer cells by stopping their growth and multiplication. They are combined with other medications to treat various lymphatic and solid cancers.
Interaction of Bucelon 60mg Injection with other drugs
Inform your physician regarding any prescribed medicines, over-the-counter medications, nutritional or vitamin supplements, and herbal products that you are taking or have taken before the treatment. Certain medications may interact with Bucelon 60mg Injection and can cause potential side effects.Â
More Information about Bucelon 60mg Injection
Unopened vials of bucelon 60 mg injection should be stored under refrigerated conditions between 2°C to 8°C (36°F to 46°F). Unused medications should be disposed of properly. Keep it out of sight and reach of children.
How to consume Bucelon 60mg Injection
Your physician will decide the formulation, dose, and duration of this therapy. The dose of Bucelon 60 mg injection depends on your blood cancer. If you are prescribed the injection, your healthcare professional will administer the injection. Do not self-administer. The injection is administered as an intravenous infusion into the vein. Don't stop the medication until or unless your doctor advises. If you missed the dose, do not take double the doses. Inform your physician about your missed dose.
Safety Advices for Bucelon 60mg Injection
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Pregnancy
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If you are pregnant or planning to get pregnant, ask your doctor or pharmacist for advice before taking this medicine. This medicine can cause infertility. It applies to men and women because Bucelon 60 mg injection may harm your sperm or eggs. It may have harmful effects on your baby.
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Breast Feeding
 ÂIf you are breastfeeding or plan to breastfeed your baby, talk to your physician because the drug may secrete in breast milk.Â
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Lungs
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It is unknown whether Bucelon 60mg Injection can be given to patients with lung diseases. Please inform your doctor if you have any lung problems.Â
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Liver
  Discuss with your physician before taking this medicine if you have liver problems.
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Alcohol
 ÂIt is not known whether it is safe to consume alcohol with Bucelon 60mg Injection. Please consult your doctor.Â
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Driving
  It is not known whether it is safe to consume alcohol with Bucelon 60mg Injection. Please consult your doctor.
Side Effects of Bucelon 60mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all medications cause side effects, not everyone gets them. Bucelon 60 mg injection causes the following side effectsÂ
Severe
Myelosuppression (decreased bone marrow activity)Â
Common side effectsÂ
- Thalassemia
- Skin rashes
- Hair loss
- Patches of dark skin
- Blood in urine
- Decrease in the number of blood cells and platelets
- Nausea and vomiting
- Jaundice
- Infertility and sterility
- Pneumonia Syndrome
- Itching
Word of Advice
Inform the doctor if the patient has taken radiotherapy priorly to the treatment. If you have any other medical conditions like heart disease, lung, kidney, or liver problems. Tell your doctor if you have any symptoms of gout (pain and swollen joints caused by uric acid crystals). During or after administration of the injection, if you face itchy skin, fever, excessive sweating, rigors or chills, or difficulty in breathing, inform your doctor immediately.
FAQs
Q 1. Can Bucelon 60 mg injection cause infertility?
Yes, Bucelon 60 mg injection can cause infertility in men and women because it affects the sperm cells and egg. Consult the doctor before taking this medication.
Q 2. How is Bucelon 60 mg injection administered?
Bucelon 60 mg injection form is given through an intravenous route into the vein by healthcare professionals.
Q 3. Can Bucelon 60 mg injection be used during pregnancy?
No, it is highly unsafe to use this medication during pregnancy as it can cause harmful effects on the developing fetus.
Q 4. Are there any special precautions patients should be aware of before starting treatment?
Patients should inform the physician about the pregnancy, breastfeeding or planning for a family. Patients should also inform about past medical and medication history.
Q 5. What is the package insert that comes with Bucelon 60 mg injection?
The package insert contains all the scientific information (indications, uses, side effects, safety and warning, contraindications) about the drug.
Q 6. Does bucelon 60 mg injection cause permanent hair loss?
Yes, Bucelon 60 mg injection causes hair loss. Consult the physician about excessive hair loss
Q 7. What does Bucelon 60 mg injection look like?
Bucelon 60 mg injection comes in clear glass vials containing 60 mg of the drug in a 10 ml sterile solution.
Fact Box of Bucelon 60mg Injection
| Molecule Name: Busulfan | Therapeutic class: Anticancer  |
| Pharmacological class: Alkylating agent - Alkyl sulfonates | Indication: 1. Chronic myelogenous leukemia 2. Hematopoietic progenitor cell transplantation 3. Polycythaemia vera 4. Thrombocythemia 5. Myelofibrosis 6. Hemoglobinopathies 7. Congenital metabolic diseases |
References
- Aspen, Electronic Medicines Compendium(EMC) (Revised on: July 2020) https://www.medicines.org.uk/emc/product/4653/pil#gref  (Accessed: December 14, 2022).
- Busulfan (Revised on: May 19, 2015) National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/drugs/busulfan  (Accessed: December 14, 2022).
- Anton Wellstein, Giuseppe Giaccone, Michael B. Atkins, and Edward A. Sausville, Pharmacotherapy of Neoplastic disease: cytotoxic drugs, Goodman & Gilman’s Pharmacological Basis of Therapeutics, 13th Edition, 2018, 1167-1174.
- Buggia I, Locatelli F, Regazzi MB, Zecca M. Busulfan. Ann Pharmacother. 1994 Sep;28(9):1055-62. doi: 10.1177/106002809402800911. PMID: 7803883.
Disclaimer
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