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Nintib 100mg Capsule
Prescription Required
Salt Composition : Nintedanib
Manufacturer : CIPLA LTD
Origin of Medicine : India
10 Capsule(s) In A Strip
Introduction to Nintib 100mg Capsule
Nintib 100mg capsule consists of the active ingredient Nintedanib. It belongs to the medication class known as tyrosine kinase inhibitors. It treats idiopathic pulmonary fibrosis, chronic fibrosing interstitial lung disease, and systemic sclerosis-associated interstitial lung disease. Talk to your physician if you are on blood thinning medications or have recently undergone surgery. Use effective contraception while receiving this capsule and continue to use it for three months, even after receiving the final dose. Consult your doctor for effective contraception because the birth control pills may not work properly on women. Â
Before starting the treatment, inform your doctor if you have any medical conditions, such as liver and heart problems. Before starting the treatment, your doctor may conduct a liver function test at the regular interval of the first three months. Notify your doctor if you have a history of bleeding or blood clots (arterial thromboembolic). Nintib 100mg may cause liver function impairment (hepatic impairment) and embryo-fetal toxicity.Â
Consult your doctor if you have any of these underlying conditions. The most common side effect of Nintib 100mg is nausea, vomiting, diarrhea, fever, skin ulcer, gastrointestinal perforation, altered liver function values, and decreased appetite. headache, weight loss, hypertension. Inform your doctor immediately if you experience any side effects.
Uses of Nintib 100mg Capsule
- Idiopathic pulmonary fibrosis.
- Chronic fibrosing lung diseases with a progressive phenotype
- Systemic sclerosis
Therapeutic Effects of Nintib 100mg Capsule
Nintib 100mg works by inhibiting receptor multiple tyrosine kinases (RTKs) enzyme that develops and progresses lung fibrosis (scarring). Inhibiting these enzymes reduces the development of fibrous tissue in the lungs.
Interaction of Nintib 100mg Capsule with other drugs
Inform your healthcare professional about all the medicines you take, including prescription, over-the-counter, nutritional and vitamin supplements, and herbal products. Certain medications include a P-glycoprotein (P-gp), CYP3A4 inhibitor, Ketoconazole, Anticoagulants, s St. John’s wort, Laxatives, and other drugs, interacting with Nintib 100mg may reduce effectiveness by causing undesirable side effects.Â
More Information about Nintib 100mg Capsule
- Before starting the treatment, it is recommended to perform a liver function test
- Store at the room temperature of 20°C to 25°C
- Protect from light and moisture
- Keep out of reach and sight of children and pets.
How to consume Nintib 100mg Capsule
Take Nintib 100mg as advised by your physician. Swallow the medicine with a glass of water. Do not crush, chew, or open the medicine. Your doctor will decide the correct dose and duration for you based upon your age, body weight and disease condition. Do not stop taking this medicine unless your doctor advises you to stop.
Safety Advices for Nintib 100mg Capsule
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Pregnancy
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Nintib 100mg is unsafe to use during pregnancy as it may cause birth defects or death to the unborn baby. Report to your doctor if you are pregnant or think you may be pregnant, or planning for the pregnancy before starting the treatment.Â
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Breast Feeding
 ÂTaking Nintib 100mg while breastfeeding may be unsafe because it may affect the child. Therefore, talk with your doctor to get more information.
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Lungs
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Consult your doctor if you experience symptoms like pneumonia or any other lung-related condition while taking Nintib 100mg. Â
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Liver
  Inform your physician if you have liver problems because Nintib 100mg should be used cautiously with this condition. Before starting treatment, your physician conducts the liver function test regularly for the first three months.
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Alcohol
 ÂIt is unknown whether consuming alcohol while taking a Nintib 100mg capsule is safe. Please speak with your physician.Â
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Driving
  While taking Nintib 100mg, driving or using machines is unsafe because it may cause nausea, changes in vision, vomiting, etc. Talk to your doctor for more information.Â
Side Effects of Nintib 100mg Capsule
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious
- Bronchitis
- Myocardial infarction
- Bleeding problems
- Pneumonia
- Major bleeding
- Yellow eyes, dark urine, pain in the upper right side of the stomach
- Severe stomach cramps, bloating, fever, and chills
- Chest pressure or pain on the left side of the body
- Increased protein in the urine (proteinuria)
Common
- Nausea, vomiting, diarrhea
- Fever
- Skin ulcer
- Gastrointestinal perforation
- Altered liver function values
- Decreased appetite
- Headache
- Weight loss
- Hypertension
Word of Advice
Inform your physician if you have bleeding problems, hypertension, heart problems or weak blood vessels. Inform your physician if you experience allergic reactions to Nintib 100mg . Notify your physician if you have recently undergone a surgery as this medicine affects the process of wound healing. Consult your physician and use an effective method of contraception while on this treatment and even after the treatment for three months. Abnormalities, such as dark or brown urine, bruises, bleeding than usual, or jaundice, must be notified immediately to your doctor. Avoid smoking while taking Nintib 100mg because it may reduce the effectiveness of the medicine.
FAQs
Q 1. How does Nintib 100mg work in the body?
Nintib 100mg works by inhibiting several signaling pathways involved in the formation of scar tissue in the lungs. It targets the activity of certain enzymes and growth factors that promote the growth of fibroblasts, which are the cells responsible for producing collagen and other proteins that form scar tissue in the lungs.
Q 2. Can Nintib 100mg cure idiopathic pulmonary fibrosis (IPF)?
Nintib 100mg is not a cure for idiopathic pulmonary fibrosis (IPF). It is a medication that can help slow the progression of the disease by reducing the formation of scar tissue in the lungs. It is important to continue taking Nintib 100mg as your doctor prescribes, even if you start feeling better.
Q 3. How can I manage diarrhea while taking Nintib 100mg?
If you experience diarrhea while taking Nintib 100mg , staying hydrated by drinking plenty of fluids is important. Your doctor may also recommend over-the-counter medications or prescription medications to help manage your diarrhea. If your diarrhea is severe or persistent, you should contact your doctor.
Q 4. Can Nintib 100mg cause liver damage?
Nintib 100mg may cause liver function abnormalities, which may indicate liver damage. It is important to have regular blood tests to monitor your liver function while taking Nintib 100mg . If you experience symptoms of liver damage, such as jaundice or abdominal pain, you should contact your doctor immediately.
Q 5. What dosage of Nintib 100mg should I take?
Your doctor will decide the correct dose and duration for you based on your age, body weight, and disease condition. Do not stop taking Nintib 100mg unless your doctor advises you to stop. As with all medications, it is important to follow the dosage instructions provided by your healthcare provider and to consult them for any questions or concerns.
Q 6. Why is liver enzyme getting elevated during treatment with Nintib 100mg ?
The reason for this elevation is not completely understood, but it is thought to be related to the drug's effects on certain enzymes involved in liver function. The elevation in liver enzymes is generally mild and temporary and typically resolves on its own or with dose adjustment of the Nintib 100mg capsule.
Fact Box of Nintib 100mg Capsule
Molecule name: Nintedanib | Therapeutic class: Antifibrotic drug |
Pharmacological class: Tyrosine Kinase inhibitors | Indications: 1. Idiopathic pulmonary fibrosis. 2. Chronic fibrosing lung diseases with a progressive phenotype 3. Systemic sclerosis |
References
- Boehringer Ingelheim Pharmaceuticals. Inc, [Revised on Oct 2022] [Accessed on 05th April 2023], https://content.boehringer-ingelheim.com/DAM/f0e91cee-803b-4767-8360-af1e011fc97a/ofev-us-ppi.pdf
- Boehringer Ingelheim, Electronics Medicines Compendium (EMC), [Revised on Aug 2021] [Accessed on 05th April 2023], https://www.medicines.org.uk/emc/files/pil.1786.pdf
- Boehringer Ingelheim, U.S. Food and Drug Administration, [Revised on Mar 2020], [Accessed on 05th April 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/205832s013lbl.pdf
- Lutz Wollin et al., Mode of action of Nintedanib capsule in the treatment of idiopathic pulmonary fibrosis, Eur Respir J. 2015 May; 45(5): 1434–1445. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416110/
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