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Pazokast 400mg Tablet
Prescription Required
Salt Composition : Pazopanib
Manufacturer : APRAZER HEALTHCARE PVT LTD
Origin of Medicine : India
30 Tablet(s) In A Bottle
Introduction to Pazokast 400mg Tablet
Pazokast 400mg tablet contains the active substance pazopanib. It is an antineoplastic drug that belongs to the class tyrosine kinase inhibitor. It is used in adults to treat advanced kidney cancer or has spread to other organs. It is also indicated to treat certain forms of soft-tissue sarcoma, a type of cancer affecting the supportive tissues of the body. This medicine works by preventing the activity of proteins involved in the growth and spread of cancer cells.
Do not take Pazokast 400mg tablet if you are allergic to Pazopanib or any other ingredients of this medicine. Before initiating the treatment, inform your physician if you have kidney, heart, lung, or liver problems, bleeding disorders, stomach or bowel problems, and thyroid problems. This tablet can raise your blood pressure. It is necessary to check your blood pressure regularly during the treatment. No dose adjustments are required for patients with kidney diseases.
Your doctor will advise you to stop Pazokast 400mg tablet at least 7 days before any surgeries or dental operations that you are undergoing, as it may affect wound healing. This medicine is not recommended for people aged under 18. This medicine can cause infertility; consult your doctor before taking this medicine. The most common side effects are diarrhea, hypertension, hair color changes, nausea, and vomiting.
Uses of Pazokast 400mg Tablet
- Advanced renal cell carcinoma
- Advanced soft tissue sarcoma
Therapeutic Effects of Pazokast 400mg Tablet
Pazokast 400mg tablet is a biological agent that acts as targeted drug therapy in cancer treatment. It is an anticancer medication that belongs to the category of tyrosine kinase inhibitors. It interferes with the growth of blood vessels inside the cancer cells by acting against a protein called Vascular Endothelial Growth Factors (VEGF) to shrink cancer cells, ultimately stopping their growth and multiplication.
Interaction of Pazokast 400mg Tablet with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications may interact with the effects of Pazokast 400mg tablet and reduce its effectiveness by causing undesirable side effects.
More Information about Pazokast 400mg Tablet
- Store Pazokast 400mg tablet in room temperature (25°C)
- Keep the injection away from the reach of children and pets.
- If you forgot to take a dose, take it as soon as you remember. However, skip the missed dose if it is nearly time for the next dose.
- Do not take a double dose to make up for a forgotten dose.
How to consume Pazokast 400mg Tablet
Your doctor will decide the dose and duration of the treatment based on your disease condition, severity, and other factors. Take the tablets as prescribed by your doctor. Do not break, crush, or chew the tablets. Swallow the tablet whole with a glass of water. Do not take this medicine with food, as it affects the absorption of this medicine. Take Pazokast 400mg tablet at least two hours after a meal or one hour before a meal.
Safety Advices for Pazokast 400mg Tablet
Pregnancy
Pazokast 400mg tablet is unsafe to administer in pregnant women because it may affect the fetus. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant. Using an effective birth control method during the treatment and for at least 2 weeks after your last dose is necessary.
Breast Feeding
Breastfeeding is not recommended in patients taking Pazokast 400mg tablet because the medicine passes into the breast milk in small amounts and may harm your baby.
Lungs
It is unknown whether Pazokast 400mg tablet can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.
Liver
Pazokast 400mg tablet is unsafe when administered in patients with severe liver diseases. Dose adjustments are necessary for moderate liver failure. Inform your physician if you have liver problems before initiating the therapy.
Alcohol
It is unknown whether it is safe to consume alcohol when taking Pazokast 400mg tablet. Consult your doctor for more advice.
Driving
Driving or operating heavy machinery is unsafe after taking Pazokast 400mg tablet because you may feel dizzy, drowsy, or have blurred vision.
Side Effects of Pazokast 400mg Tablet
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Common
- Hypertension
- Hair color change
- Increased glucose levels
- Decreased weight, decrease in appetite
- Diarrhea
- Nausea, vomiting
- Muscle and joint pain
- Headache
- Shortness of breath
- Tiredness
Serious
- Heart problems
- Bleeding from the anus, mouth
- Hypothyroidism
- Interstitial lung disease
- Infections
Word of Advice
Do not drink grapefruit juice during the treatment with this medicine, as this may increase the chance of side effects. Male patients with female partners with reproductive potential should use effective contraception during the treatment and at least 2 weeks after the last dose to prevent pregnancy. Take the tablet at about the same time each day. Your doctor will regularly do lab tests to check whether the medicine works for you.
FAQs
Q 1. What if I forgot to take Pazokast 400mg tablet?
If you forgot to take a dose, take it as soon as you remember. However, skip the missed dose if it is nearly time for the next dose. Do not take a double dose to make up the forgotten dose.
Q 2. Can Pazokast 400mg tablet induce liver toxicity?
Yes, long-term use of Pazokast 400mg tablet may induce liver toxicity or severe liver failure. Inform your physician if you have any liver disorders before starting treatment with this medicine. Your doctor may advise you to take certain blood tests to check your liver function periodically.
Q 3. Does Pazokast 400mg tablet change hair color?
Hair color change is a common side effect of Pazokast 400mg tablet therapy which usually develops gradually during a few months of therapy. Consult your doctor for more advice.
Q 4. Is anemia a side effect of Pazokast 400mg tablet?
Pazokast 400mg tablet can reduce the number of red blood cells, which transport oxygen throughout the body. A low number of red blood cells is called anemia. This may make you feel tired and short of breath. Tell your doctor or nurse if you have these symptoms.
Q 5. What are the benefits of Pazokast 400mg tablet?
Pazokast 400mg tablet is used to treat certain types of cancer (kidney, soft tissue sarcoma). It decreases the blood supply to the cancer tumor to slow tumor growth.
Fact Box of Pazokast 400mg Tablet
Molecule name: Pazopanib | Therapeutic class: Antineoplastics |
Pharmacological class: Tyrosine kinase inhibitor | Indications: 1. Advanced renal cell carcinoma 2. Advanced soft tissue sarcoma |
References
- Highlights Of Prescribing Information - Pazopanib. [Revised on 2021] [cited 2023 Mar 24]. Available from: https://www.novartis.com/us-en/sites/novartis_us/files/votrient.pdf
- Summary Of Product Characteristics - Pazopanib. [revised on 2021] [cited 2023 Mar 24]. Available from: https://www.ema.europa.eu/en/documents/product-information/votrient-epar-product-information_en.pdf
- Votrient 400 mg film coated tablets - Summary of Product Characteristics (SmPC) - (emc). www.medicines.org.uk. 2021 [cited 2023 Mar 24]. Available from: https://www.medicines.org.uk/emc/product/572/smpc
- Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
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