All Substitutes
Loading...
Disclaimer
Did you find this information helpful?
Votrient 400mg Tablet
Prescription Required
Salt Composition : Pazopanib
Manufacturer : NOVARTIS INDIA LTD
Origin of Medicine : United Kingdom
30 Tablet(s) In A Bottle
Introduction to Votrient 400mg Tablet
Votrient 400mg tablet contains the active substance pazopanib. It is an antineoplastic drug in the tyrosine kinase inhibitor class. It is used in adults to treat advanced kidney cancer that has spread to other organs.
Do not take Votrient 400mg tablet if you are allergic to Pazopanib or any other ingredients of this medicine. Before initiating the treatment, inform your physician if you have kidney, heart, lung, or liver problems, bleeding disorders, stomach or bowel problems, and thyroid problems. This tablet can raise your blood pressure, so you should check it regularly during treatment. No dose adjustments are required for patients with kidney diseases.
Your doctor will advise you to stop Votrient 400mg tablet at least 7 days before any surgeries or dental operations that you are undergoing, as it may affect wound healing. This medicine is not recommended for people aged under 18. This medicine can cause infertility; consult your doctor before taking this medicine. The most common side effects are diarrhea, hypertension, hair color changes, nausea, and vomiting.
Uses of Votrient 400mg Tablet
- Directly inhibits the growth and spread of cancer cells in conditions like advanced renal cell carcinoma.
- Helps to reduce the size and impact of tumors in conditions such as soft tissue sarcoma.
Therapeutic Effects of Votrient 400mg Tablet
Votrient 400mg tablet is a biological agent that acts as targeted drug therapy in cancer treatment. It interferes with the growth of blood vessels inside the cancer cells by acting against a protein called Vascular Endothelial Growth Factors (VEGF) to shrink cancer cells, ultimately stopping their growth and multiplication.
Interaction of Votrient 400mg Tablet with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications may interact with the effects of Votrient 400mg tablet and reduce its effectiveness by causing undesirable side effects.
More Information about Votrient 400mg Tablet
- Store Votrient 400mg tablet in room temperature (25°C)
- Keep the injection away from the reach of children and pets.
- If you forgot to take a dose, take it as soon as you remember. However, skip the missed dose if it is nearly time for the next dose.
- Take only a partial dose to make up for a forgotten dose.
How to consume Votrient 400mg Tablet
Your doctor will decide the dose and duration of the treatment based on your disease condition, severity, and other factors. Take the tablets as prescribed by your doctor. Do not break, crush, or chew the tablets. Swallow the tablet whole with a glass of water. Do not take this medicine with food, as it affects the absorption of this medicine. Take Votrient 400mg tablet at least two hours after a meal or one hour before a meal.
Safety Advices for Votrient 400mg Tablet
Pregnancy
Votrient 400mg tablet is unsafe to administer in pregnant women because it may affect the fetus. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant. Using an effective birth control method during the treatment and for at least 2 weeks after your last dose is necessary.
Breast Feeding
Breastfeeding is not recommended in patients taking Votrient 400mg tablet because the medicine passes into the breast milk in small amounts and may harm your baby.
Lungs
It is unknown whether Votrient 400mg tablet can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.
Liver
Votrient 400mg tablet is unsafe when administered in patients with severe liver diseases. Dose adjustments are necessary for moderate liver failure. Inform your physician if you have liver problems before initiating the therapy.
Alcohol
It is unknown whether it is safe to consume alcohol when taking Votrient 400mg tablet. Consult your doctor for more advice.
Driving
Driving or operating heavy machinery is unsafe after taking Votrient 400mg tablet because you may feel dizzy, drowsy, or have blurred vision.
Side Effects of Votrient 400mg Tablet
It is crucial to monitor any adverse effects and report them to your healthcare provider for appropriate management.
Common
- Hypertension
- Hair color change
- Increased glucose levels
- Decreased weight, decrease in appetite
- Diarrhea
- Nausea, vomiting
- Muscle and joint pain
- Headache
- Shortness of breath
- Tiredness
Serious
- Heart problems
- Bleeding from the anus, mouth
- Hypothyroidism
- Interstitial lung disease
- Infections
Word of Advice
Avoid consuming grapefruit juice while undergoing treatment with this medication, as it could heighten the risk of side effects. Male patients whose partners are of childbearing potential should use effective contraception during treatment and for at least two weeks after the final dose to prevent pregnancy. It is important to take the tablet consistently at the same time each day. Your doctor will conduct regular lab tests to monitor the effectiveness of the medication.
FAQs
Q 1. What is the correct way to take Votrient 400mg Tablet?
Votrient 400mg Tablet should be administered orally, once daily, or as prescribed by your healthcare provider. It is important to swallow the tablet whole with water and not to break or crush it, as altering the tablet can affect how the medication is absorbed and potentially increase side effects.
Q 2. Can I take Votrient 400mg tablet of Votrient with food?
It is recommended that Votrient 400mg Tablet be taken on an empty stomach, either 1 hour before or 2 hours after eating. Consuming it with food could necessitate a higher dosage, which may lead to an increase in side effects.
Q 3. Does Votrient 400mg tablet change hair color?
Hair color change is a common side effect of Votrient 400mg tablet therapy which usually develops gradually during a few months of therapy. Consult your doctor for more advice.
Q 4. How can I tell if Votrient 400mg Tablet is effective?
The treatment duration with Votrient 400mg Tablet varies among individuals. Your doctor will conduct regular evaluations to determine the effectiveness of the treatment and decide how long you should continue taking it.
Q 5. What are the benefits of Votrient 400mg tablet?
Votrient 400mg tablet is used to treat certain types of cancer (kidney, soft tissue sarcoma). It decreases the blood supply to the cancer tumor to slow tumor growth.
Fact Box of Votrient 400mg Tablet
Molecule name: Pazopanib | Therapeutic class: Antineoplastics |
Pharmacological class: Tyrosine kinase inhibitor | Indications: 1. Advanced renal cell carcinoma 2. Advanced soft tissue sarcoma |
References
- Highlights Of Prescribing Information - Pazopanib. [Revised on 2021] [cited 2023 Mar 24]. Available from: https://www.novartis.com/us-en/sites/novartis_us/files/votrient.pdf
- Summary Of Product Characteristics - Pazopanib. [revised on 2021] [cited 2023 Mar 24]. Available from: https://www.ema.europa.eu/en/documents/product-information/votrient-epar-product-information_en.pdf
- Votrient 400 mg film coated tablets - Summary of Product Characteristics (SmPC) - (emc). www.medicines.org.uk. 2021 [cited 2023 Mar 24]. Available from: https://www.medicines.org.uk/emc/product/572/smpc
- Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
Disclaimer
MrMed’s primary intention is to ensure that its consumers get information that is reviewed by experts, accurate and trustworthy. The information and contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on MrMed. Our mission is to support, not replace, the doctor-patient relationship.
